Systems-based discovery advances drug development.
Systems-based discovery advances drug development.
复制标题
基于系统的发现促进药物开发。
DOI：
10.1038/clpt.2013.21
复制
发表时间：
2013
影响因子：
6.7
通讯作者：
Terzic,A
中科院分区：
文献类型：
--
作者：
Waldman,SA;Terzic,A
Drug development expenditures continue to escalate, in part reflecting inefficiencies in current drug discovery paradigms. Traditional drug discovery has been dichotomous, focusing either on phenotypic effects of distinct agents in biological systems, without knowledge of respective targets, or on target‐based activities of specific molecules in cell‐free assays. Driven by advances in biology, engineering, and informatics, new paradigms integrate phenotypic with target‐based algorithms into comprehensive, systems‐level approaches offering value‐added strategies for optimized drug discovery.Clinical Pharmacology & Therapeutics(2013);934, 285–287. doi:10.1038/clpt.2013.21
