A mechanism for the initiation of allergen-induced T helper type 2 responses
A mechanism for the initiation of allergen-induced T helper type 2 responses
复制标题
DOI：
10.1038/ni1558
复制
发表时间：
2008-03-01
影响因子：
30.5
通讯作者：
Medzhitov, Ruslan
中科院分区：
文献类型：
--
作者：
Sokol, Caroline L.;Barton, Gregory M.;Medzhitov, Ruslan
后生动物寄生虫和简单蛋白过敏原都能诱导T辅助细胞2型（T（H）2）免疫应答，但先天免疫系统感知这些刺激的机制尚不清楚。此外，控制体内T（H）2分化的细胞因子的细胞来源尚未确定。在这里，我们发现嗜碱性粒细胞被激活并募集到引流淋巴结特异性地响应T（H）2诱导的过敏原攻击。此外，我们证明嗜碱性粒细胞是T（H）2诱导蛋白酶过敏原所需的辅助细胞类型。最后，我们表明嗜碱性粒细胞直接激活蛋白酶过敏原和T（H）2诱导细胞因子，包括白细胞介素4和胸腺基质淋巴细胞生成素，这是参与T（H）2分化在体内。
Both metazoan parasites and simple protein allergens induce T helper type 2 (T(H)2) immune responses, but the mechanisms by which the innate immune system senses these stimuli are unknown. In addition, the cellular source of cytokines that control T(H)2 differentiation in vivo has not been defined. Here we showed that basophils were activated and recruited to the draining lymph nodes specifically in response to T(H)2-inducing allergen challenge. Furthermore, we demonstrate that the basophil was the accessory cell type required for T(H)2 induction in response to protease allergens. Finally, we show that basophils were directly activated by protease allergens and produced T(H)2-inducing cytokines, including interleukin 4 and thymic stromal lymphopoietin, which are involved in T(H)2 differentiation in vivo.