Evidence for amelioration of ischaemic neuronal damage in the hippocampal formation by lesions of the perforant path.
Evidence for amelioration of ischaemic neuronal damage in the hippocampal formation by lesions of the perforant path.
复制标题
通过穿通路径损伤改善海马结构缺血性神经元损伤的证据。
DOI：
10.1080/01616412.1985.11739695
复制
发表时间：
1985
影响因子：
1.9
通讯作者：
Gage,FH
中科院分区：
文献类型：
--
作者：
Wieloch,T;Lindvall,O;Blomqvist,P;Gage,FH
在大鼠中研究了两条兴奋性传入通路的损伤对完全性脑缺血后海马细胞损伤的影响。与对照侧和对照组相比，横断穿通通路的损伤导致损伤同侧海马CA_1区细胞损伤显著减少。另一方面，穹窿海马伞的损伤没有显著影响。我们建议，保护作用的穿通路径病变是由于删除的amatergic/amatergic途径和释放这些兴奋性氨基酸可能是一个关键因素，脑缺血后神经元坏死。
The effect of lesions of two excitatory afferent pathways on the cellular damage in the hippocampus following complete cerebral ischaemia was investigated in the rat Lesions transecting the perforant path led to a significant decrease in cellular damage in the hippocampal CA1 region ipsilateral to the lesion as compared to the contatterai side and to control. Lesions of the fimbria-fornix, on the other hand, had no significant effects. We propose that the protective effect of the perforant path lesions is due to removal of glutamatergic/aspartergic pathways and that release of these excitatory amino acids might be a critical factor for neuronal necrosis following cerebral ischaemia.