Initial neutrophil lymphocyte ratio is superior to platelet lymphocyte ratio as an adverse prognostic and predictive factor in metastatic colorectal cancer
Initial neutrophil lymphocyte ratio is superior to platelet lymphocyte ratio as an adverse prognostic and predictive factor in metastatic colorectal cancer
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作为转移性结直肠癌的不良预后和预测因素，初始中性粒细胞淋巴细胞比率优于血小板淋巴细胞比率
DOI：
10.1007/s12032-012-0439-x
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发表时间：
2013-03-01
期刊：
影响因子：
3.4
通讯作者：
Xia, Liangping
中科院分区：
文献类型：
--
作者：
He, Wenzhuo;Yin, Chenxi;Xia, Liangping
炎症指标在晚期结直肠癌中的预后，尤其是预测价值尚未确定。因此，研究并比较了初发转移性结直肠癌（mCRC）患者的中性粒细胞淋巴细胞比率（NLR）和血小板淋巴细胞比率（PLR）。样本收集自2005年至2010年间中山大学肿瘤防治中心首次诊断为mCRC的243例患者。NLR（p< 0.001）、PLR（p= 0.008）和CEA（p< 0.001）升高被确定为总生存期（OS）的统计学显著不良预后因素，而只有NLR（p= 0.029）和CEA（p< 0.001）被验证为独立预测因子。单变量分析发现，NLR（p< 0.001）、PLR（p= 0.023）和CEA（p< 0.001）升高是一线化疗无进展生存期（PFS）的统计学显著不良预测因素，而NLR（p= 0.013）和CEA（p= 0.001）是独立的。此外，我们观察到NLR和CEA水平均升高的患者与仅升高一次或均未升高的患者的OS（p< 0.001）和PFS（p< 0.001）存在显著差异。NLR、PLR和CEA是mCRC中OS和PFS的显著预测因子。然而，只有NLR和CEA是独立的。当与CEA结合时，NLR可能导致改善的预后预测因子。
The prognostic, especially predictive, values of inflammation indexes in advanced colorectal cancer were not established. Therefore, the both values of neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) in patients with initially metastatic colorectal cancer (mCRC) were investigated and compared. Samples were collected from 243 patients who were initially diagnosed with mCRC between 2005 and 2010 in the Sun Yat-sen University Cancer Center. Elevated NLR (p< 0.001), PLR (p= 0.008), and CEA (p< 0.001) were identified as statistically significant poor prognostic factors for overall survival (OS), while only NLR (p= 0.029) and CEA (p< 0.001) were validated as independent predictors. Univariate analysis identified elevated NLR (p< 0.001), PLR (p= 0.023), and CEA (p< 0.001) as statistically significant poor predict factors for the progression-free survival (PFS) of first-line chemotherapy, while NLR (p= 0.013) and CEA (p= 0.001) were independent. In addition, we observed significantly different OS (p< 0.001) and PFS (p< 0.001) among patients who had elevations in both NLR and CEA levels and those having one elevation or neither elevation. NLR, PLR, and CEA were significant predictors of OS and PFS in mCRC. However, only NLR and CEA play as independent. When coupled with CEA, NLR may lead to improved prognostic predictors.