Brain systems mediating cognitive interference by emotional distraction
Brain systems mediating cognitive interference by emotional distraction
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DOI：
10.1523/jneurosci.5042-05.2006
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发表时间：
2006-02-15
影响因子：
5.3
通讯作者：
McCarthy, G
中科院分区：
文献类型：
--
作者：
Dolcos, F;McCarthy, G
灵活的行为取决于我们应对干扰目标实现的干扰刺激的能力。情绪干扰可能会对目标导向的行为造成特别的破坏，但这些有害影响是通过什么神经系统传递的，目前尚不清楚。我们使用事件相关功能磁共振成像来研究情绪和非情绪干扰对延迟反应工作记忆(WM)任务的影响。正如预期的那样，这项任务在典型的WM区域(背外侧前额叶皮质和外侧顶叶皮质)的延迟期内激发了强劲的活动。在延迟期内出现情绪干扰物，在典型的情绪处理区域(杏仁核和前额叶腹外侧皮质)激发强烈的活动，同时引起WM区域的相对失活，并损害WM操作。这些结果提供了第一个直接证据，表明情绪分心对正在进行的认知过程的有害影响涉及与“冷”执行处理相关的背部神经系统和与“热”情绪处理相关的腹侧系统之间的相互作用。
Flexible behavior depends on our ability to cope with distracting stimuli that can interfere with the attainment of goals. Emotional distracters can be particularly disruptive to goal-oriented behavior, but the neural systems through which these detrimental effects are mediated are not known. We used event-related functional magnetic resonance imaging to investigate the effect of emotional and nonemotional distracters on a delayed-response working memory (WM) task. As expected, this task evoked robust activity during the delay period in typical WM regions (dorsolateral prefrontal cortex and lateral parietal cortex). Presentation of emotional distracters during the delay interval evoked strong activity in typical emotional processing regions (amygdala and ventrolateral prefrontal cortex) while simultaneously evoking relative deactivation of the WM regions and impairing WM performance. These results provide the first direct evidence that the detrimental effect of emotional distracters on ongoing cognitive processes entails the interaction between a dorsal neural system associated with "cold" executive processing and a ventral system associated with "hot" emotional processing.