Large body size and sedentary lifestyle during childhood and early adulthood and esophageal squamous cell carcinoma in a high-risk population
Large body size and sedentary lifestyle during childhood and early adulthood and esophageal squamous cell carcinoma in a high-risk population
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DOI：
10.1093/annonc/mdr494
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发表时间：
2012-06-01
影响因子：
50.5
通讯作者：
Dawsey, S. M.
中科院分区：
文献类型：
--
作者：
Etemadi, A.;Golozar, A.;Dawsey, S. M.
工作背景：鲜为人知的是肥胖和体力活动在年轻的年龄与随后的食管鳞状细胞癌（ESCC）的风险的关联：患者和方法：2003年至2007年，我们进行了一项病例对照研究，在伊朗东北部的高风险人群。招募了300名ESCC病例和571名匹配的对照。每个人都被展示了一个标准的象形图，以报告15岁和30岁时的身体大小。人口统计学和健康相关的信息，包括在这些年龄段的体力活动也被收集。在女性中，15岁[比值比（OR）3.2，95%置信区间（CI）1.3-7.7]和30岁（OR 3.1; 95% CI 1.1-8.5）时的最后两个象形图与ESCC相关，但在男性中则无关。15岁（OR 3.3，95% CI 1.3-8.3）和30岁（OR 18.2，95% CI 3.9-86.2）时久坐工作也仅与女性ESCC风险相关。女性在15岁时增加的风险仍然很高，后来减少身体尺寸，而女性谁成为非常肥胖，只有在30岁时没有表现出显着增加risk.Conclusion：这些结果突出了早期的生活方式的改变在癌症预防的背景下，特别是在妇女的重要性。
Background: Little is known about the association of obesity and physical activity at young ages with subsequent risk of esophageal squamous cell carcinoma (ESCC).Patients and methods: Between 2003 and 2007, we conducted a case-control study in a high-risk population in northeastern Iran. Three hundred ESCC cases and 571 matched controls were recruited. Each individual was shown a standard pictogram, to report body size at ages 15 and 30. Demographic and health-related information, including physical activity at these ages was also collected.Results: In the fully adjusted models, very obese body size (last two pictograms) at age 15 [odds ratio (OR) 3.2, 95% confidence interval (CI) 1.3-7.7] and age 30 (OR 3.1; 95% CI 1.1-8.5) were associated with ESCC in women, but not in men. Sedentary work at age 15 (OR 3.3, 95% CI 1.3-8.3) and 30 (OR 18.2, 95% CI 3.9-86.2) were also associated with ESCC risk in women only. The increased risk in women at age 15 remained high after later reduction in body size, while women who became very obese only at age 30 did not show a significantly increased risk.Conclusion: These results highlight the importance of early lifestyle modifications in the context of cancer prevention, particularly in women.