EFFECTS OF CURCUMIN, DEMETHOXYCURCUMIN, BISDEMETHOXYCURCUMIN AND TETRAHYDROCURCUMIN ON 12-O-TETRADECANOYLPHORBOL-13-ACETATE-INDUCED TUMOR PROMOTION
EFFECTS OF CURCUMIN, DEMETHOXYCURCUMIN, BISDEMETHOXYCURCUMIN AND TETRAHYDROCURCUMIN ON 12-O-TETRADECANOYLPHORBOL-13-ACETATE-INDUCED TUMOR PROMOTION
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DOI：
10.1093/carcin/16.10.2493
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发表时间：
1995-10-01
期刊：
影响因子：
4.7
通讯作者：
CONNEY, AH
中科院分区：
文献类型：
--
作者：
HUANG, MT;MA, W;CONNEY, AH
商业级姜黄素（类似于77%姜黄素、17%脱甲氧基姜黄素和3%双脱甲氧基姜黄素）被广泛用作食品中的黄色着色剂和香料。在本研究中，局部应用商业级姜黄素，纯姜黄素或去甲氧基姜黄素对12-O-十四酰基佛波醇-13-乙酸酯（TPA）诱导的鸟氨酸脱羧酶活性和TPA诱导的鸟氨酸脱羧酶活性增加具有同等有效的抑制作用。在7，12-二甲基苯并[a]蒽引发的小鼠皮肤中，双脱甲氧基姜黄素和四氢姜黄素的活性较低。在另外的研究中，我们发现商业级姜黄素、纯姜黄素、脱甲氧基姜黄素和双脱甲氧基姜黄素对TPA诱导的小鼠耳部炎症以及TPA诱导的培养的JB 6（P+）细胞转化具有大致相同的有效抑制作用。结果表明，纯姜黄素和去甲氧基姜黄素（商业级姜黄素的主要成分）具有与商业级姜黄素相同的抑制TPA诱导的肿瘤促进的有效抑制作用，但双去甲氧基姜黄素和四氢姜黄素的活性较低。
Commercial grade curcumin (similar to 77% curcumin, 17% demethoxycurcumin and 3% bisdemethoxycurcumin) is widely used as a yellow coloring agent and spice in foods, In the present study topical application of commercial grade curcumin, pure curcumin or demethoxycurcumin had an equally potent inhibitory effect on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced increases in ornithine decarboxylase activity and TPA-induced tumor promotion in 7,12-dimethylbenz[a]anthracene-initiated mouse skin, Bisdemethoxycurcumin and tetrahydrocurcumin mere less active. In additional studies we found that commercial grade curcumin, pure curcumin, demethoxycurcumin and bisdemethoxycurcumin had about the same potent inhibitory effect on TPA-induced inflammation of mouse ears, as well as TPA-induced transformation of cultured JB6 (P+) cells. Tetrahydrocurcumin was less active, The results indicate that pure curcumin and demethoxycurcumin (the major constituents of commercial grade curcumin) have the same potent inhibitory effects as commercial grade curcumin for inhibition of TPA-induced tumor promotion, but bisdemethoxycurcumin and tetrahydrocurcumin are less active.