The transfer of immunity from mother to child
The transfer of immunity from mother to child
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DOI：
10.1111/j.1749-6632.2003.tb06049.x
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发表时间：
2003-01-01
期刊：
影响因子：
--
通讯作者：
Telemo, E
中科院分区：
文献类型：
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作者：
Hanson, LÅ;Korotkova, M;Telemo, E
新生儿的免疫系统从出生时的较小规模迅速增长，主要是通过暴露于通常在出生时和出生后从母亲那里获得的肠道微生物群。在建立免疫系统的同时，婴儿受到胎盘免疫球蛋白抗体的支持，这种抗体也含有抗独特型抗体，可能还会主动为后代做准备。第二种免疫转移方式是通过牛奶进行的。有许多主要的保护成分，包括分泌性IgA(SIgA)抗体和乳铁蛋白。母乳喂养的婴儿比非母乳喂养的婴儿对许多常见感染有更好的保护。母乳喂养似乎还通过抗独特型、摄取乳汁淋巴细胞、细胞因子等方式积极刺激婴儿的免疫系统。因此，母乳喂养的孩子在未来几年继续获得更好的保护，免受各种感染。在母乳喂养的婴儿中，疫苗反应通常也会增强。对某些免疫性疾病，如过敏和乳糜泻，也有持久的保护作用。
The newborn's immune system grows fast from a small size at birth by exposure primarily to the intestinal microflora normally obtained from the mother at and after birth. While building up its immune system, the infant is supported by the transplacental IgG antibodies, which also contain anti-idiotypic antibodies, possibly also actively priming the offspring. The second mode of transfer of immunity occurs via the milk. Numerous major protective components, including secretory IgA (SIgA) antibodies and lactoferrin, are present.The breastfed infant is better protected against numerous common infections than the non-breastfed. Breastfeeding also seems to actively stimulate the infant's immune system by anti-idiotypes, uptake of milk lymphocytes, cytokines, etc. Therefore, the breastfed child continues to be better protected against various infections for some years. Vaccine responses are also often enhanced in breastfed infants. Long-lasting protection against certain immunological diseases such as allergies and celiac disease is also noted.