Hemodynamic analysis of capillary in finger nail-fold using computational fluid dynamics and image estimation
Hemodynamic analysis of capillary in finger nail-fold using computational fluid dynamics and image estimation
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DOI：
10.1016/j.mvr.2010.10.006
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发表时间：
2011-01-01
影响因子：
3.1
通讯作者：
Huang, Tzung-Chi
中科院分区：
文献类型：
--
作者：
Shih, Tzu-Ching;Zhang, Geoffrey;Huang, Tzung-Chi
毛细血管中的红细胞(RBC)动力学是许多疾病的有用诊断工具。以往的研究表明，利用图像配准技术，光流估计(OFE)能够准确地计算出红细胞的速度。应用计算流体力学(CFD)方法对6例指甲皱毛细血管内红细胞速度进行了计算。假设截面为圆形，将二维毛细血管图像重建为三维图像。在管壁上采用了无滑移边界条件。用OFE计算红细胞进入每根毛细血管的初始速度。比较了CFD(V-CFD)和OFE(V-OFE)计算的毛细血管多点运动速度。计算得到的红细胞流速范围为56~685亩m/S，48个计算点的平均差值(V-CFD-V-OFE)为-2.66+/-18.61亩/S，除1个点(47分)外，其余各点的平均值为0.03+/-0.12亩m/S，说明CFD对指甲皱毛细血管的红细胞流速计算具有较高的精度。(C)2010 Elsevier Inc.保留所有权利。
Red blood cell (RBC) dynamics in capillaries is a useful diagnostic tool for many diseases. Previous study showed that optical flow estimation (OFE) is capable of accurately calculating RBC velocities using image registration technique. The computational fluid dynamics (CFD) method is explored in this study to calculate the RBC velocity in capillaries of finger nail-fold for six cases. The two-dimensional capillary images were reconstructed to three-dimensional, assuming circular cross sections. The no-slip boundary conditions were applied on the vessel walls. The initial velocity of the RBC going into each capillary was calculated by OFE. The velocities of multiple points along each capillary calculated by CFD, V-CFD, were compared with OFE calculations, V-OFE. The calculated RBC velocity was in the range of 56-685 mu m/s. The average difference (V-CFD - V-OFE) with one standard deviation is -2.66 +/- 18.61 mu m/s for all the 48 calculation points, and 0.03 +/- 0.12 mu m/s for all except one points (47 points), indicating that CFD can provide a reasonable accuracy in RBC velocity calculation in finger nail-fold capillaries. (C) 2010 Elsevier Inc. All rights reserved.