FEMTOSECOND LASER TISSUE INTERACTIONS - RETINAL INJURY STUDIES
FEMTOSECOND LASER TISSUE INTERACTIONS - RETINAL INJURY STUDIES
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DOI：
10.1109/jqe.1987.1073235
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发表时间：
1987-10-01
影响因子：
2.5
通讯作者：
FUJIMOTO, JG
中科院分区：
文献类型：
--
作者：
BIRNGRUBER, R;PULIAFITO, CA;FUJIMOTO, JG
我们首次报道了飞秒时间范围内激光与组织相互作用的研究。研究了高强度飞秒激光对灰兔视网膜的损伤阈值和损伤机制。在625 nm处使用持续时间为80fs的单个激光脉冲进行曝光。使用荧光素血管造影术和眼底镜能见度标准分别测量0.75和4.5μJ的ED50损伤阈值，评估204次激光照射。对选定的皮损进行了包括光学和电子显微镜在内的超微结构研究。结果表明，视网膜中的初级能量沉积发生在黑色素中，然而，与较长脉冲产生的激光损伤相比，J范围内超过100×阈值的曝光并不会产生明显更严重的损伤或出血。这表明在暴露于飞秒激光脉冲的组织中存在着一种非线性的损伤限制机制。
We report the first study of laser-tissue interaction in the femtosecond time regime. Retinal damage thresholds and mechanisms produced by exposure to high-intensity femtosecond laser pulses were investigated in chinchilla grey rabbits. Exposures were performed using single laser pulses of 80 fs duration at 625 nm. ED50injury thresholds of 0.75 and 4.5 μJ were measured using fluorescein angiographic and ophthalmoscopic visibility criteria evaluating 204 laser exposures. Ultrastructural studies including light and electron microscopy were performed on selected lesions. Results suggest that the primary energy deposition in the retina occurs in melanin, However, in contrast to laser injuries produced by longer pulses, exposures of more than 100 × threshold in theJ range did not produce significantly more severe lesions or hemorrhage. This suggests the presence of a nonlinear damage limiting mechanics in tissue exposed to femtosecond laser pulses.