URTICARIA-PIGMENTOSA - A REVIEW OF 67 PEDIATRIC CASES
URTICARIA-PIGMENTOSA - A REVIEW OF 67 PEDIATRIC CASES
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DOI：
10.1111/j.1525-1470.1994.tb00560.x
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发表时间：
1994-06-01
影响因子：
1.5
通讯作者：
ZAMBRANO, A
中科院分区：
文献类型：
--
作者：
AZANA, JM;TORRELO, A;ZAMBRANO, A
肥大细胞增生症是一种肥大细胞增生的疾病，可能出现在婴儿期，儿童期或成年期。我们研究了连续67例色素性荨麻疹患者（33例男性，34例女性），并对其进行了全面评估，以确定是否存在全身受累。病变发生的年龄从出生到11岁不等，大多数发生在生命的第一年。瘙痒是主要症状。进行血液学和血清化学特征、放射学骨骼调查和骨髓抽吸。3例患者出现轻度贫血。在8例患者中观察到放射学骨病变。6例患者的骨髓穿刺结果显示轻微变化，仅1例患者的肥大细胞数量增加。这种病往往会自行消退。这项前瞻性研究强调儿童色素性荨麻疹的良性性质。
Mastocytosis is a disorder of mast cell proliferation that may appear during infancy, childhood, or adulthood. We studied 67 consecutive patients (33 males, 34 females) with urticaria pigmentosa and assessed them fully to determine the presence of systemic involvement. Ages at onset of lesions ranged from birth to 11 years, with most developing in the first year of life. Pruritus was the primary symptom. Hematologic and serum chemistry profile, radiologic skeletal surveys, and bone marrow aspirations were performed. Slight anemia was present in three patients. Radiologic bone lesions were observed in eight. Bone marrow aspirates showed slight changes in six patients, with only an increased number of mast cells in an additional patient. The disease tended to resolve spontaneously. This prospective study emphasizes the benign nature of pediatric urticaria pigmentosa.