Properties of the stochastic energization-relaxation channel model for vectorial ion transport.

Properties of the stochastic energization-relaxation channel model for vectorial ion transport.
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矢量离子传输的随机赋能-弛豫通道模型的特性。

DOI:
10.1016/s0006-3495(00)76674-4
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发表时间:
2000
影响因子:
3.4
通讯作者:
T. Fukami
T. Fukami
中科院分区:
生物学3区
文献类型:
--
作者:
E. Muneyuki;T. Fukami

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提出了一种离子泵蛋白质初级主动转运的模型。该模型,“能量化-弛豫通道模型”,描述了一个离子泵作为一个多离子通道,通过外部能量供应经历两个构象状态之间的随机转换。当沿沿着离子输运路径的电势分布不对称时,由跃迁引起净离子通量。在该模型中,构象变化和离子输运的耦合是随机的和松散的。该模型定性地再现了已知的主动运输性能,如离子浓度梯度和膜电位对运输速率的影响,以及在高离子浓度下对离子运输的抑制。我们进一步研究了各种参数对该模型的离子输运性质的影响。在一定条件下,耦合效率几乎为100%。
A model for the primary active transport by an ion pump protein is proposed. The model, the "energization-relaxation channel model," describes an ion pump as a multiion channel that undergoes stochastic transitions between two conformational states by external energy supply. When the potential profile along ion transport pathway is asymmetrical, a net ion flux is induced by the transitions. In this model, the coupling of the conformational change and ion transport is stochastic and loose. The model qualitatively reproduces known properties of active transport such as the effect of ion concentration gradient and membrane potential on the rate of transport and the inhibition of ion transport at high ion concentration. We further examined the effect of various parameters on the ion transport properties of this model. The efficiency of the coupling was almost 100% under some conditions.
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发表时间: 1996-04-02
期刊: BIOCHEMISTRY
影响因子: 2.9
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