A robust test for assortative mating.
A robust test for assortative mating.
复制标题
选型交配的稳健测试。
DOI：
10.1038/sj.ejhg.5200430
复制
发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Thomson,G
中科院分区：
文献类型：
--
作者：
Genin,E;Ober,C;Weitkamp,L;Thomson,G
由于种族偏好和人群分层等混杂因素，在人群中进行随机交配检测很困难。对于HLA，高水平的多态性是一个额外的问题，因为夫妻共享相同的单倍型是罕见的。集中在一个种族同质的人口，在HLA基因座的多态性水平是有限的，可能提供了最好的情况下，检测非随机交配。然而，这些种群往往是遗传隔离，其中可能存在近亲繁殖，其程度难以量化和解释。我们已经开发了一个测试随机交配的多等位基因位点，是强大的分层和近亲繁殖。该测试依赖于配偶双方父母的基因型信息的可用性。该测试的重点是夫妻双方的父母之间存在等位基因共享的家庭，以便潜在的配偶可以共享等位基因。用A表示感兴趣的基因座处的共享等位基因，则在随机交配的假设下，杂合亲本AX应该将等位基因A与等位基因X一样频繁地传递给其后代。当存在正（负）选择性交配时，A将比X传播得更多（更少）。在许多情况下计算了检验的功效。Hutterite人群的高分辨率HLA单倍型的数据进行了重新调查，提出的测试。当考虑到共享单倍型的亲本来源时，该测试检测到显著的负选择性交配。
Testing for random mating in human populations is difficult due to confounding factors such as ethnic preference and population stratification. With HLA, the high level of polymorphism is an additional problem since it is rare for couples to share the same haplotype. Focus on an ethnically homogeneous population, where levels of polymorphism at HLA loci are more limited, may provide the best situation in which to detect non-random mating. However, such populations are often genetic isolates where there may be inbreeding to an extent that is difficult to quantify and account for. We have developed a test for random mating at a multiallelic locus that is robust to stratification and inbreeding. This test relies on the availability of genotypic information from the parents of both spouses. The focus of the test is on families where there is allele sharing between the parents of both spouses, so that potential spouses could share an allele. Denoting the shared allele at the locus of interest by A, then under the assumption of random mating, heterozygous parents AX should transmit allele A equally as frequently as allele X to their offspring. When there is positive (negative) assortative mating, A will be transmitted more (less) often than X. The power of the test has been computed in a number of situations. Data on high resolution HLA haplotypes from the Hutterite population were reinvestigated by the proposed test. The test detects significant negative assortative mating when the parental origin of the shared haplotype is taken into account.