Association between 1425G/A SNP in PRKCH and ischemic stroke among Chinese and Japanese populations: A meta-analysis including 3686 cases and 4589 controls
Association between 1425G/A SNP in PRKCH and ischemic stroke among Chinese and Japanese populations: A meta-analysis including 3686 cases and 4589 controls
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中国和日本人群中 PRKCH 中 1425G/A SNP 与缺血性脑卒中的关联：一项包含 3686 例病例和 4589 例对照的荟萃分析
DOI：
10.1016/j.neulet.2011.10.047
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发表时间：
2012-01-06
影响因子：
2.5
通讯作者：
Sheng, Wenli
中科院分区：
文献类型：
--
作者：
Li, Jiaoxing;Luo, Man;Sheng, Wenli
目的：本研究采用Meta分析的方法，探讨蛋白激酶C eta基因PRKCH 1425 G/A SNP与中国和日本人群缺血性脑卒中的相关性。研究方法：检索MEDLINE、PubMed、中国生物医学数据库、中国知网、万方数据库，并检索到2011年9月已发表的关于PRKCH 1425 G/A SNP与缺血性脑卒中的病例对照研究。确定严格的选择标准和排除标准，并使用固定或随机效应模型计算合并比值比（OR）和95%置信区间（Cl），以确定遗传关联的强度。通过计算纳入研究的失效安全数进一步评价发表偏倚。结果：5项研究，包括3686例病例和4589例对照，通过了所有标准，因此被纳入荟萃分析。异质性检验显示，两项荟萃分析的P值（分别为P=0.76、0.24）均大于0.05，因此采用固定效应模型。PRKCH基因1425 G/A SNP与缺血性脑卒中的相关性有统计学意义（OR=1.34; 95% CI，1.22-1.47），与腔隙性脑梗死的相关性更强（OR=1.44; 95% CI，1.28-1.63）。1425 G/A SNP在PRKCH缺血性脑卒中和腔隙性脑梗死中的失效安全数（N-fs 0.05）分别为59和44，大于纳入分析的研究数量。结论：在中国和日本人群中，PRKCH基因1425 G/A多态性与缺血性卒中，特别是腔隙性脑梗死相关。需要对中风的不同亚型进行更多的研究，以确认其他亚洲人群的结果。(C)2011爱思唯尔爱尔兰有限公司保留所有权利。
Aims: Meta-analysis was performed to investigate the association between 1425G/A SNP in PRKCH (the gene encoding for protein kinase C eta) and ischemic stroke among Chinese and Japanese populations. Methods: The databases of MEDLINE, PubMed, Chinese Biomedical Database, China National Knowledge Infrastructure, and WANFANG DATA until September 2011 were searched for published case-control studies on 1425G/A SNP in PRKCH and ischemic stroke. Strict selection criteria and exclusion criteria were determined, and pooled odds ratio (OR) and the 95% confidence interval (Cl) were calculated using a fixed or random effects model to determine the strength of the genetic association. The publication bias was further evaluated by calculating the fail-safe number in the included studies. Results: Five studies, comprising 3686 cases and 4589 controls, passed all the criteria and therefore were included in the meta-analysis. Test for heterogeneity showed that P values (P=0.76, 0.24, respectively) in the two meta-analyses were both greater than 0.05, therefore the fixed effects model was performed. Statistically significant association between 1425G/A SNP in PRKCH and ischemic stroke was identified (OR=1.34; 95% CI, 1.22-1.47), and the association was even stronger between 1425G/A SNP in PRKCH and lacunar infarction (OR=1.44; 95% CI, 1.28-1.63). The fail-safe number (N-fs0.05) for 1425G/A SNP in PRKCH with ischemic stroke and lacunar infarction was 59 and 44, respectively, which were greater than the number of studies included in the analyses. Conclusions: SNP 1425G/A in PRKCH was associated with ischemic stroke, particularly lacunar infarction, in Chinese and Japanese populations. More studies of different subtypes of stroke need to be done to confirm the results in other Asian populations. (C) 2011 Elsevier Ireland Ltd. All rights reserved.