ULTRAFAST IMAGING OF ULTRASOUND CONTRAST AGENTS
ULTRAFAST IMAGING OF ULTRASOUND CONTRAST AGENTS
复制标题
DOI：
10.1016/j.ultrasmedbio.2009.05.020
复制
发表时间：
2009-11-01
影响因子：
2.9
通讯作者：
Tanter, Mickael
中科院分区：
文献类型：
--
作者：
Couture, Olivier;Bannouf, Souad;Tanter, Mickael
超声造影剂在破坏后的消失可以提供关于其环境的有用信息。然而，这种瞬态现象的体内声学成像（其具有毫秒量级的持续时间）需要常规超声扫描仪无法达到的高帧速率。在这篇文章中，超快成像应用于微泡跟踪使用128元素的线性阵列和弹性成像扫描仪。在无壁组织体模中流动的造影剂用高强度破坏脉冲进行声穿透，随后是以5 kHz PRF发射的一系列平面波。在对回波进行计算机波束成形后，获得描绘微泡演变的复合图像的集合。微泡的后向散射似乎在破裂后（4ms）的第一图像中增加，并且在接下来的一百毫秒中在指数衰减后减少。这种微泡动态取决于高强度脉冲的长度和幅度。此外，封闭的微泡被发现显着不同，从他们的自由流动的同行在他们的溶解曲线。超快成像提供的高时间分辨率可以帮助在分子成像期间区分靶向微泡。（电子邮件：olicou@gmail.com）（C）2009年世界医学和生物学超声联合会。
The disappearance of ultrasound contrast agents after disruption can provide useful information on their environment. However, in vivo acoustical imaging of this transient phenomenon, which has a duration on the order of milliseconds, requires high frame rates that are unattainable by conventional ultrasound scanners. In this article, ultrafast imaging is applied to microbubble tracking using a 128-element linear array and an elastography scanner. Contrast agents flowing in a wall-less tissue phantom are insonified with a high-intensity disruption pulse followed by a series of plane waves emitted at a 5 kHz PRF. A collection of compounded images depicting the evolution of microbubbles is obtained after the echoes are beamformed in silico. The backscattering of the microbubbles appears to increase in the first image after disruption (4 ms) and decrease following an exponential decay in the next hundred milliseconds. This microbubble dynamic depends on the length and amplitude of the high-intensity pulse. Furthermore, confined microbubbles are found to differ significantly from their free-flowing counterparts in their dissolution curves. The high temporal resolution provided by ultrafast imaging could help distinguish targeted microbubbles during molecular imaging. (E-mail: olicou@gmail.com) (C) 2009 World Federation for Ultrasound in Medicine & Biology.