HITHERTO UNRECOGNIZED ARTERIOLES WITHIN HEPATOCELLULAR-CARCINOMA
HITHERTO UNRECOGNIZED ARTERIOLES WITHIN HEPATOCELLULAR-CARCINOMA
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DOI：
10.1002/path.1711740311
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发表时间：
1994-11-01
影响因子：
7.3
通讯作者：
YAMAMOTO, Y
中科院分区：
文献类型：
--
作者：
HIMENO, H;ENZAN, H;YAMAMOTO, Y
应用抗α-平滑肌肌动蛋白单克隆抗体，用光镜、电镜及形态计量学方法研究了人肝癌血管的分布。α-平滑肌肌动蛋白阳性的小动脉从未在非癌区域的小叶或假小叶中观察到，但在肝细胞癌中常见。形态测定分析表明，这些小动脉的直径大多在10和25 μ m之间。肿瘤内小动脉的形态与非癌区域门脉束中的常规动脉的形态有很大不同。丰富的肿瘤内小动脉的存在可以解释血管造影的肝细胞癌的血供丰富，并提供了其对缺氧的敏感性和动脉栓塞作为治疗策略的病理基础。
The distribution of blood vessels in human hepatocellular carcinoma was studied with the anti-a-smooth muscle actin monoclonal antibody by light and electron microscopy, and with morphometric analysis. a-smooth muscle actin-positive arterioles were never observed in lobules or pseudolobules of non-cancerous areas, but were frequently seen within hepatocellular carcinomas. Morphometric analysis revealed that most of these arterioles measured between 10 and 25 mu m in diameter. The morphology of intratumoural arterioles differed considerably from that of conventional arteries in the portal tracts of the non-cancerous area. The presence of abundant intratumoural arterioles can explain the angiographic hypervascularity of hepatocellular carcinoma and provides a pathological basis for its susceptibility to hypoxia and for arterial embolization as a therapeutic strategy.