Synthesis and in vitro evaluation of N-alkyl-3-hydroxy-3-(2-imino-3-methyl-5-oxoimidazolidin-4-yl)indolin-2-one analogs as potential anticancer agents.
Synthesis and in vitro evaluation of N-alkyl-3-hydroxy-3-(2-imino-3-methyl-5-oxoimidazolidin-4-yl)indolin-2-one analogs as potential anticancer agents.
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DOI：
10.1016/j.bmcl.2010.06.042
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发表时间：
2010-08-01
影响因子：
2.7
通讯作者：
Crooks, Peter A.
中科院分区：
文献类型：
--
作者：
Penthala, Narsimha Reddy;Yerramreddy, Thirupathi Reddy;Madadi, Nikhil Reddy;Crooks, Peter A.
A series of novel 3-hydroxy-3-(2-imino-3-methyl-5-oxoimidazolidin-4-yl)indolin-2-one analogs (3) have been synthesized under microwave irradiation and conventional heating methods. These analogs were evaluated for in vitro cytotoxicity against a panel of 57 human tumor cell lines. Compound 3o had GI50 values of 190 nM and 750 nM against A549/ATTC non-small cell lung cancer and LOX IMVI melanoma cell lines, respectively, and both 3n and 3o exhibited GI50 values ranging from 2–5 μM against CCRF-CEM, HL-60(TB), K-562, MOLT-4, and RPMI-8226 leukemia cell lines. These results indicate that N-4-methoxybenzyl-3-hydroxy-(2-imino-3-methyl-5-oxo-4-yl)indolin-2-one analogs may be useful leads for anticancer drug development.
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影响因子：
7.3
作者：
Hall MD;Salam NK;Hellawell JL;Fales HM;Kensler CB;Ludwig JA;Szakács G;Hibbs DE;Gottesman MM
通讯作者：
Gottesman MM
影响因子：
7.3
作者：
Vine, Kara L.;Locke, Julie M.;Bremner, John B.
通讯作者：
Bremner, John B.
DOI：
10.1107/s1600536809004875
发表时间：
2009-02-21
期刊：
Acta crystallographica. Section E, Structure reports online
影响因子：
--
作者：
Penthala NR;Reddy TR;Parkin S;Crooks PA
通讯作者：
Crooks PA
DOI：
10.1107/s1600536809033881
发表时间：
2009-09-12
期刊：
Acta crystallographica. Section E, Structure reports online
影响因子：
--
作者：
Penthala NR;Reddy TR;Parkin S;Crooks PA
通讯作者：
Crooks PA
影响因子：
3.5
作者：
Vine, Kara L.;Locke, Julie M.;Bremner, John B.
通讯作者：
Bremner, John B.