Specificity for the glucose-6-P inhibition site of hexokinase.
Specificity for the glucose-6-P inhibition site of hexokinase.
复制标题
己糖激酶葡萄糖-6-P 抑制位点的特异性。
DOI：
10.1016/0003-9861(74)90086-1
复制
发表时间：
1974
影响因子：
3.9
通讯作者：
D. Kosow
中科院分区：
文献类型：
--
作者：
I. A. Rose;J. V. Warms;D. Kosow
Inhibition of the three animal hexokinase isozymes by the following glucose-6-Panalogs has been determined: α-glucose-1,6-P2, α- and β-methyl glucose-6-P, α- and β-glucose-6-P, 2-Cl- and 4F-glucose-6-P, 5-deoxyglucose-6-P, glucose-6-sulfate, and δ-gluconolactone-6-P. Although both anomers of glucose-6-Pwere about equally active inhibitors, the β-methyl derivative was inactive. Generally the α-methyl and α-PO3−derivatives were good inhibitors though weaker than glucose-6-Pexcept in the case of hexokinase II for which α-glucose-1,6-P2was an excellent inhibitor.
