Differences in Genotype, Clinical Features, and Inflammatory Potential of Borrelia burgdorferi sensu stricto Strains from Europe and the United States
Differences in Genotype, Clinical Features, and Inflammatory Potential of Borrelia burgdorferi sensu stricto Strains from Europe and the United States
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DOI：
10.3201/eid2205.151806
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发表时间：
2016-05-01
影响因子：
11.8
通讯作者：
Strle, Klemen
中科院分区：
文献类型：
--
作者：
Cerar, Tjasa;Strle, Franc;Strle, Klemen
从欧洲和美国的迁徙红斑患者中分离的伯氏疏螺旋体按基因型、感染的临床特征和炎症潜在性进行了比较。外表面蛋白C分析和多位点序列分析表明，这两个区域的菌株代表了不同的基因型别。斯洛文尼亚伯氏杆菌感染的临床特征与另外两种疏螺旋体感染相似。在欧洲会引起疾病，而来自美国的伯氏杆菌菌株与更严重的疾病有关。此外，来自美国的伯氏杆菌菌株诱导外周血单核细胞分泌与先天和Th1适应性免疫反应相关的更高水平的细胞因子和趋化因子，而来自欧洲的菌株诱导更多的Th17相关反应。因此，来自欧洲和美国的相同伯氏杆菌种的菌株代表着不同的克隆谱系，这些克隆谱系在毒力和炎症潜力方面存在差异。
Borrelia burgdorferi sensu stricto isolates from patients with erythema migrans in Europe and the United States were compared by genotype, clinical features of infection, and inflammatory potential. Analysis of outer surface protein C and multilocus sequence typing showed that strains from these 2 regions represent distinct genotypes. Clinical features of infection with B. burgdorferi in Slovenia were similar to infection with B. afzelii or B. garinii, the other 2 Borrelia spp. that cause disease in Europe, whereas B. burgdorferi strains from the United States were associated with more severe disease. Moreover, B. burgdorferi strains from the United States induced peripheral blood mononuclear cells to secrete higher levels of cytokines and chemokines associated with innate and Th1-adaptive immune responses, whereas strains from Europe induced greater Th17-associated responses. Thus, strains of the same B. burgdorferi species from Europe and the United States represent distinct clonal lineages that vary in virulence and,inflammatory potential.