Deadly teamwork: neural cancer stem cells and the tumor microenvironment.

Deadly teamwork: neural cancer stem cells and the tumor microenvironment.
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DOI:
10.1016/j.stem.2011.04.013
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发表时间:
2011-05-06
期刊:
影响因子:
23.9
通讯作者:
Rich, Jeremy N.
Rich, Jeremy N.
中科院分区:
医学1区
文献类型:
--
作者:
Lathia, Justin D.;Heddleston, John M.;Venere, Monica;Rich, Jeremy N.

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神经癌表现为细胞层次结构,顶端有自我更新的致癌干细胞(CSCs)。维持CSCs的指导性线索是由内在网络和利基微环境产生的。CSC与微环境的关系是复杂的,因为CSC可以改变其所处的环境,而外力可以诱导细胞层次的可塑性。
Neural cancers display cellular hierarchies with self-renewing tumorigenic cancer stem cells (CSCs) at the apex. Instructive cues to maintain CSCs are generated by both intrinsic networks and the niche microenvironment. The CSC-microenvironment relationship is complex as CSCs can modify their environment and extrinsic forces induce plasticity in the cellular hierarchy.
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