[Investigation of the genetics in allergic rhinitis. The 3rd report--HLA class I and II specificities of Japanese cedar pollinosis].
[Investigation of the genetics in allergic rhinitis. The 3rd report--HLA class I and II specificities of Japanese cedar pollinosis].
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过敏性鼻炎的遗传学研究。
DOI：
10.3950/jibiinkoka.91.509
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
T. Ishikawa
中科院分区：
文献类型：
--
作者：
Y. Kitao;Y. Sadanaga;M. Uno;N. On;K. Masuyama;T. Ishikawa
36例日本雪松（J.C.）本文对花粉症患者和66名正常人进行了HLA Ⅰ类（A、B、C）和Ⅱ类（DR、DQW、DRW）抗原的特异性研究。患者包括20例对J.C. 16例对J.C.以及其它抗原如屋尘螨和/或果园草。通过临床症状、皮试及鼻腔激发试验确诊。和血清IgE抗体滴度对J.C.所有患者对所有这些测试均呈阳性，而所有对照组对测试均呈阴性。结果如下。1. HLA-DQW 3在36例患者中的检出率明显高于66例对照组。（患者：86.1%，对照：65.2%，P<0.05，Pc<0.1）20例J.C.过敏者HLA-A26阳性率较高。66个对照组中，（患者：45%，对照组：16。7%，P<0.01，Pc<0.05）3. 16例对含有J.C.在66个对照组中，（患者人数：93人。8%，对照：65.2%，P<0.05，Pc<0.1）4.在患者组中，所有具有HLA-A26的个体都具有HLA-DQW 3。结果表明，HLA-A26与HLA-DQW 3之间可能存在连锁不平衡关系。提示与J.C.花粉症可能位于HLA-DQW 3位点或其附近。
Thirty six patients with Japanese cedar (J.C.) pollinosis and 66 normal controls were investigated for clarifing the specificities of HLA class I (A, B, C,) and II (DR, DQW, DRW) antigens. The patients consisted of 20 patients allergic to J.C. alone and 16 patients allergic to J.C. and other antigens such as housedust mite and/or orchard grass simultaneously. The diagnosis of the disease was made by clinical symptoms, skin test and nasal provocation test with J .C. and serum IgE antibody titer to J.C. All of the patients were positive to all of these tests , and all of the controls were negative to the tests. The results were as follows. 1. The incidence of HLA-DQW3 was more higher in the 36 patients than that in the 66 controls. (Patients: 86.1%, Controls: 65.2%, P<0.05, Pc<0.1) 2. The incidence of HLA-A26 was more higher in 20 patients allergic to J.C. alone than that in the 66 controls. (Patients: 45%, Controls: 16. 7%, P<0.01, Pc<0.05) 3. The incidence of HLA DQW3 was more higher in the 16 patients allergic to multiple antigens contained J.C. than that in the 66 controls. (Patients: 93. 8%, Controls: 65.2%, P<0.05, Pc<0.1) 4. In the patients group, all of the individuals who had HLA-A26 had HLA-DQW3. From the results obtained , it is considered that there may be a linkage disequilibrium relationship between HLA-A26 and HLA DQW3 in the patients . And it is suggested that the genes concerning with J.C. pollinosis may be located the locus of HLA-DQW3 or close to it.