Hospital-acquired infections due to gram-negative bacteria.
Hospital-acquired infections due to gram-negative bacteria.
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DOI：
10.1056/nejmra0904124
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发表时间：
2010-05-13
期刊：
影响因子：
--
通讯作者：
Hooper DC
中科院分区：
文献类型：
--
作者：
Peleg AY;Hooper DC
医院获得性感染最常与机械通气、侵入性医疗器械或外科手术相关。革兰氏阴性菌是导致30%以上医院获得性感染的原因，并且在医院获得性肺炎中占主导地位。它们在上调或获得抗生素耐药性机制方面非常有效，特别是在抗生素选择压力的存在下。这篇综述更新了临床医生应该知道的关于这些经常危及生命的感染的信息。
Hospital-acquired infections are most commonly associated with mechanical ventilation, invasive medical devices, or surgical procedures. Gram-negative bacteria are responsible for more than 30% of hospital-acquired infections and predominate in hospital-acquired pneumonia. They are highly efficient at up-regulating or acquiring mechanisms of antibiotic drug resistance, especially in the presence of antibiotic selection pressure. This review updates what clinicians should know about these often life-threatening infections.