Biogenic amine concentrations in traumatized spinal cords of cats. Effect of drug therapy.
Biogenic amine concentrations in traumatized spinal cords of cats. Effect of drug therapy.
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DOI：
10.3171/jns.1974.40.1.0052
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发表时间：
1974
影响因子：
4.1
通讯作者：
N. Naftchi;M. Demeny;V. Decrescito;J. Tomasula;E. Flamm;J. Campbell
中科院分区：
文献类型：
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作者：
N. Naftchi;M. Demeny;V. Decrescito;J. Tomasula;E. Flamm;J. Campbell
✓测定五组猫脊髓中去甲肾上腺素（NE）、多巴胺（DA）、血清素（5-HT）和组胺（HIST）的浓度。一组仅行椎板切除术；第二组未治疗组在T-9水平受到400 gm-cm的冲击。并与类似创伤后应用epsilon氨基己酸（EACA）、甲基强的松龙琥珀酸钠（MP）以及EACA和MP联合治疗的三组进行比较。创伤后1小时，在脊髓的吻侧、中部和尾侧三个1厘米的节段测量生物胺。与去板对照相比，撞击后三个节段的NE浓度没有变化，撞击（中部）区域的NE浓度也不高于吻侧或尾侧部位。虽然处理过的动物脊髓内NE含量比板层切除的对照组有所下降，但下降并不显著。而DA浓度在撞击后显著升高。
✓ Concentrations of norepinephrine (NE), dopamine (DA), serotonin (5-HT), and histamine (HIST) were determined in spinal cords of five groups of cats. One group underwent laminectomy only; a second untreated group received a 400 gm-cm impact at the T-9 level. These were compared with three groups treated with epsilon aminocaproic acid (EACA), methyl prednisolone sodium succinate (MP), and a combination of EACA and MP after similar trauma. The biogenic amines were measured in three 1-cm segments of the cord, rostral, middle, and caudal, 1 hour after trauma. There was no change in NE concentration in any of the three segments after impact compared with laminectomized controls, nor was the NE concentration in the impacted (middle) area higher than that in the rostral or caudal sites. Although the NE content of the cord in treated animals decreased compared to that of laminectomized controls, the decrease was not significant. The concentration of DA, however, significantly increased after impact and significa...