Hepatitis C virus infection:: in vivo and in vitro models
Hepatitis C virus infection:: in vivo and in vitro models
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DOI：
10.1111/j.1365-2893.2007.00918.x
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发表时间：
2007-11-01
影响因子：
2.5
通讯作者：
Blum, H. E.
中科院分区：
文献类型：
--
作者：
Brass, V.;Moradpour, D.;Blum, H. E.
近年来，对丙型肝炎病毒分子生物学的研究取得了重大进展。虽然黑猩猩是唯一已建立的丙型肝炎病毒感染的动物模型，但已建立了几个体内和体外模型，使我们能够研究病毒生命周期的各个方面。特别是，复制子系统和重组感染性病毒粒子的产生彻底改变了对丙型肝炎病毒-RNA复制的研究，使病毒生命周期的所有步骤，包括病毒颗粒的进入和释放，都可以进行系统分析。下面我们将对不同的体内和体外丙型肝炎病毒感染模型进行综述。
Major advances in the understanding of the molecular biology of hepatitis C virus (HCV) have been made recently. While the chimpanzee is the only established animal model of HCV infection, several in vivo and in vitro models have been established that allow us to study various aspects of the viral life cycle. In particular, the replicon system and the production of recombinant infectious virions revolutionized the investigation of HCV-RNA replication and rendered all steps of the viral life cycle, including entry and release of viral particles, amenable to systematic analysis. In the following we will review the different in vivo and in vitro models of HCV infection.