Improved oxygenation in a randomized trial of inhaled nitric oxide for persistent pulmonary hypertension of the newborn
Improved oxygenation in a randomized trial of inhaled nitric oxide for persistent pulmonary hypertension of the newborn
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DOI：
10.1542/peds.100.5.e7
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发表时间：
1997-11-01
期刊：
影响因子：
8
通讯作者：
Kourembanas, S
中科院分区：
文献类型：
--
作者：
Wessel, DL;Adatia, I;Kourembanas, S
Objective.目的：探讨吸入一氧化氮（NO）对临床疗效的影响。一项前瞻性随机试验，患者转诊至一家大型中心的3级托儿所。临床医生未对分组设盲。从对照组到NO治疗组的患者交叉没有被排除。我们随机选择了49名机械通气新生儿，这些新生儿在临床和超声心动图上都有严重PPHN（动脉血氧分压[PaO2]）的证据，
Objective. To determine the effect of inhaled nitric oxide (NO) on clinical ouDesign. A prospective, randomized trial of patients referred to a level 3 nursery in a single large center. Clinicians were not masked to group assignment. Crossover of patients from control to NO treatment was not permitted.Methods. We randomized 49 mechanically ventilated newborns, transferred to our center with clinical and echocardiographic evidence of severe PPHN (arterial oxygen tension [PaO2]