Clinical outcome of dogs with grade-II mast cell tumors treated with surgery alone:: 55 cases (1996-1999)
Clinical outcome of dogs with grade-II mast cell tumors treated with surgery alone:: 55 cases (1996-1999)
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DOI：
10.2460/javma.2001.218.1120
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发表时间：
2001-04-01
期刊：
影响因子：
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通讯作者：
Withrow, SJ
中科院分区：
文献类型：
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作者：
Séguin, B;Leibman, NF;Withrow, SJ
设计-回顾研究：动物55只，检查病历，记录信号；肿瘤的位置和大小；分期状况；局部复发、转移、死亡或最后一次随访的日期；手术切缘状况；既往手术、术后并发症和死亡原因。后续信息是通过重新检查或与主人或推荐的兽医进行电话交谈获得的。结果：55条狗的60个肿瘤被纳入研究。中位随访时间为540天。3只(5%)肥大细胞瘤局部复发，中位复发时间为62天，6只(11%)犬在不同皮肤部位发生另一肥大细胞瘤，中位复发时间为240天。3只狗(5%)发生转移；转移的中位时间为158天。14只狗死亡，3只与肥大细胞瘤有关，7只与肥大细胞瘤无关。中位生存期分别为151天、841天和827天。在研究期间，46只狗(84%)没有肥大细胞肿瘤。无法确定可靠的预后因素。结论和临床相关性-结果表明，在完全切除I级肥大细胞瘤后，可能不需要额外的局部治疗，而且大多数狗不需要全身治疗。
Objective-To determine outcome for dogs with grade-it mast cell tumors treated with surgery alone.Design-Retrospective study.Animals-55 dogs.Procedures-Medical records were examined, and signalment; location and size of tumor; staging status; dates of local recurrence, metastasis, death, or last follow-up examination; status of surgical margins; previous surgery, postoperative complications; and cause of death were recorded. Follow-up information was obtained via reexamination or telephone conversations with owners or referring veterinarians. Univariate analysis was performed to identify prognostic factors.Results-60 tumors in 55 dogs were included. Median follow-up time was 540 days. Three (5%) mast cell tumors recurred locally, median time to local recurrence was 62 days, Six (11%) dogs developed another mast cell tumor at a different cutaneous location; median time to a different location was 240 days. Three (5%) dogs developed metastases; median time to metastasis was 158 days. Fourteen dogs died; 3 deaths were related to mast cell tumor, and 7 were unrelated. The relationship with mast cell tumor was not known for 4. Median survival times were 151, 841, and 827 days, respectively, for these 3 groups. Forty-six (84%) dogs were free of mast cell tumors during the study period. A reliable prognostic factor could not be identified.Conclusions and Clinical Relevance-Results suggest that additional local treatment may not be required after complete excision of grade-it mast cell tumors and that most dogs do not require systemic treatment.