Identification and function of human cytomegalovirus microRNAs
Identification and function of human cytomegalovirus microRNAs
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DOI：
10.1016/j.jcv.2007.11.024
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发表时间：
2008-03-01
影响因子：
8.8
通讯作者：
Nelson, Jay
中科院分区：
文献类型：
--
作者：
Grey, Finn;Nelson, Jay
microRNA是一类广泛的非编码基因，通过转录后抑制来调节基因表达。这些小RNA在进化上是保守的，并且可能是大多数真核生物中存在的基因调控的基本机制。迄今为止，通过生物信息学和克隆研究的结合，已经鉴定出超过100种病毒miRNA。在这篇综述中，我们讨论了使用生物信息学的鉴定HCMV的miRNA，也为潜在的目标转录本的发现。这些研究将使我们能够确定病毒miRNA的功能作用，并更好地了解病毒基因调控。(C)2007 Elsevier B.V.保留所有权利。
microRNAs are an extensive class of non-coding genes that regulate gene expression through post-transcriptional repression. These small RNAs are evolutionarily conserved and are likely to be a basic mechanism of gene regulation present within most eukaryotic organisms. Over 100 viral miRNAs have been identified to date through a combination of bioinformatics and cloning studies. In this review we discuss the use of bioinformatics for the identification of HCMV miRNAs and also for the discovery of potential target transcripts. Such studies will enable us to define the functional role of viral miRNAs and gain a better understanding of viral gene regulation. (C) 2007 Elsevier B.V. All rights reserved.