Selection of Arteriolipidosis-Prone Rats (ALR)
Selection of Arteriolipidosis-Prone Rats (ALR)
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易患动脉脂质沉积症的大鼠 (ALR) 的选择
DOI：
10.1536/ihj.18.602
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发表时间：
1977
期刊：
影响因子：
--
通讯作者：
Y. Yamori
中科院分区：
文献类型：
--
作者：
Y. Yamori
通过反复饲养具有更高反应性高胆固醇血症的大鼠，成功地从SHR中选择了动脉脂质过多倾向大鼠（ALR）。当喂食HFC饮食几周后，它们迅速发展为高胆固醇血症，肠系膜和肠系膜基底动脉中出现环状脂肪沉积。ALR的建立证明，动脉粥样硬化的发生不仅与高血压有关，还与胆固醇代谢的遗传异常有关。
Arteriolipidosis-prone rats (ALR) were successfully selected among SHR by repeatedly breeding rats with a greater reactive hypercholesterolemia. When fed on a HFC diet for few weeks, they rapidly developed hypercholesterolemia and ring-like fat deposits in mesenteric and cerebrobasal arteries. The establishment of ALR has proven that not only hypertension but also possible genetic abnormality in cholesterol metabolism is important for atherogenesis.