High spectral and spatial resolution MRI of breast lesions: Preliminary clinical experience
High spectral and spatial resolution MRI of breast lesions: Preliminary clinical experience
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DOI：
10.2214/ajr.04.1704
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发表时间：
2006-01-01
影响因子：
5
通讯作者：
Karczmar, GS
中科院分区：
文献类型：
--
作者：
Medved, M;Newstead, GM;Karczmar, GS
目标。在以前的研究中，高光谱和空间分辨率(HISS)的回波平面光谱成像(EPSI)被成功地应用于人类乳房，获得了更好的对比度、解剖细节和对造影剂的敏感性。为了在临床环境中测试HISS，我们使用HISS MRI对30名可疑乳房病变的妇女进行成像。对可疑乳腺病变的女性在增强前后使用1.5T的EPSI(平面分辨率为0.63毫米，频谱分辨率为2.6赫兹)进行扫描。合成强度与每个体素的水信号峰高成正比的图像，并与标准的临床脂肪饱和图像和早期动态减影图像进行比较。对比增强前后的HISS图像，以评估造影剂对水共振结构的影响。结果：HISS图像在病变显着性、边缘清晰度和内部清晰度方面明显优于标准临床图像。即使它们是在注射造影剂之前获得的。脂肪抑制更完整和均匀，细节在HISS图像上比传统的脂肪饱和图像显示得更清楚，因此，HISS图像通常更容易评估病变。造影剂影响的改变通常在空间和光谱上是不均匀的。结论：HISS扫描被成功地整合到标准的临床检查中，并在注射造影剂之前提供了诊断有用的图像。因此，有可能根据增强前的高分辨率光谱信息来确定可疑病变的特征。这些信息和关于造影剂效果的信息可能会潜在地提高乳腺MRI的特异性。
OBJECTIVE. In previous research, high spectral and spatial resolution (HiSS) echo-planar spectroscopic imaging (EPSI) was successfully applied to the human breast, obtaining improved contrast, anatomic detail, and sensitivity to contrast agents. To test HiSS in the clinical setting, we used HiSS MRI to image 30 women with suspicious breast lesions.SUBJECTS AND METHODS. Women with suspicious breast lesions were scanned before and after contrast administration using EPSI at 1.5 T (0.63-mm in-plane resolution, 2.6-Hz spectral resolution). Images with intensity proportional to the water signal peak height in each voxel were synthesized and compared with standard clinical fat-saturated and early dynamic subtraction images. Pre- and postcontrast HiSS images were compared to assess the effect of the contrast agent on water resonance structure.RESULTS. HiSS images scored significantly better than standard clinical images in lesion conspicuity, margin definition, and internal definition. even though they were acquired before contrast agent injection. Fat suppression was more complete and uniform and detail was shown on HiSS images more clearly than on conventional fat-saturation images, Thus, HiSS images often allowed easier evaluation of the lesion. Contrast agent-affected changes were often spatially and spectrally inhomogeneous.CONCLUSION. HiSS scans were successfully integrated into standard clinical examinations and provided diagnostically useful images before contrast agent injection. Thus, it might be possible to characterize suspicious lesions on the basis of precontrast high-resolution spectral information. This information and information about the effect of contrast agents could potentially improve the specificity of breast MRI.