BEHAVIORAL AND BIOCHEMICAL CONSEQUENCES FOLLOWING ACTIVATION OF 5HT1-LIKE AND GABA RECEPTORS IN THE DORSAL RAPHE NUCLEUS OF THE RAT
BEHAVIORAL AND BIOCHEMICAL CONSEQUENCES FOLLOWING ACTIVATION OF 5HT1-LIKE AND GABA RECEPTORS IN THE DORSAL RAPHE NUCLEUS OF THE RAT
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DOI：
10.1016/0028-3908(88)90058-5
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发表时间：
1988-10-01
影响因子：
4.7
通讯作者：
OAKLEY, NR
中科院分区：
文献类型：
--
作者：
HIGGINS, GA;BRADBURY, AJ;OAKLEY, NR
本文报道了向中缝背核（DRN）注射5-HT_（1-like）受体化合物5-羧酰胺色胺（5-CT）、8-羟基-2-（二正丙基氨基）四氢萘（8-OH-DPAT）、丁螺环酮和伊沙匹隆以及GABA激动剂蝇蕈醇后的行为和生化反应。所有化合物都增加了强光下的社会互动，不熟悉的条件下，并增加了Vogel冲突测试中的惩罚反应。在这些焦虑模型中，蝇蕈醇、5-CT和8-OH-DPAT的有效剂量范围为5-25倍时，诱导了明显的体温降低和身体姿势变平。另一方面，丁螺环酮在所有动物中未能诱导核心温度的显著降低或产生明显的姿势扁平化，即使剂量是焦虑模型中有效剂量的100倍。向中缝背核注射蝇蕈醇、5-CT、8-OH-DPAT和丁螺环酮后，额叶皮质、海马和下丘脑的5-HIAA：5-HT比值均降低。这些研究结果，连同可用的电生理数据表明，这些行为反应是一个抑郁症的中缝背核的细胞的发射的结果，与相应的减少5-HT在前脑的功能活动。
The behavioural and biochemical response to the 5-HT1-like receptor compounds, 5-carboxamidotryptamine (5-CT), 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), buspirone and ipsapirone and the GABA agonist, muscimol, injected into the dorsal raphe nucleus (DRN) are reported. All compounds increased social interaction under high light, unfamiliar conditions and increased punished responding in a Vogel conflict test. At doses ranging from 5-25 times greater than those which were effective in these anxiety models, muscimol, 5-CT and 8-OH-DPAT induced a marked hypotermia and a flattening of body posture. Buspirone, on the other hand, failed to induced a significant reduction in core temperature or produce a marked flattening of posture in all animals, even at doses 100 times those effective in anxiety models. Following injection of muscimol, 5-CT, 8-OH-DPAT and buspirone into the dorsal raphe nucleus, all tended to reduce the 5-HIAA:5-HT ratios in the frontal cortex, hippocampus and hypothalamus. These findings, together with available electrophysiological data suggest that these behavioural responses are a consequence of a depression of the firing of cells in the dorsal raphe nucleus, with a corresponding decrease in functional activity of 5-HT in the forebrain.