Adverse effects of maternal enterovirus infection on the fetus and placenta.
Adverse effects of maternal enterovirus infection on the fetus and placenta.
复制标题
母体肠道病毒感染对胎儿和胎盘的不良影响。
DOI：
10.1086/514139
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Abzug,MJ
中科院分区：
文献类型：
--
作者：
Palmer,AL;Rotbart,HA;Tyson,RW;Abzug,MJ
评估了先天性肠病毒感染小鼠模型的妊娠结局。将妊娠小鼠在妊娠6 - 7天（早期）静脉注射泰勒氏小鼠脑脊髓炎病毒（TMEV）或bhk21细胞裂解液（对照），6或12天后处死，观察其胎盘和胎儿。感染TMEV并在6天后处死的胎鼠的胎盘和胎儿，其肉眼和组织学异常的发生率均很高（50%-87%）。接种tmev后12天处死的感染母鼠胎盘-胎儿畸形率较低（25%-57%），但完全妊娠丢失率增加42%。妊娠丢失（9%）和胎盘胎儿异常（4%-7%）在对照动物中不常见。感染母鼠的胎儿畸形和胎盘感染发生率超过胎儿病毒感染率，提示TMEV感染通过直接胎儿损伤或间接胎盘损害对妊娠产生不利影响。
Gestational outcome in a murine model of congenital enterovirus infection was evaluated. Pregnant mice were inoculated intravenously with Theiler's murine encephalomyelitis virus (TMEV), a murine enterovirus, or with BHK 21 cell lysate (control) at 6–7 days of gestation (early) and sacrificed 6 or 12 days later, and their placentas and fetuses were studied. High rates of gross and histologic abnormalities (50%–87%) were seen in placentas and fetuses from dams infected with TMEV and sacrificed 6 days later. TMEV-infected dams sacrificed 12 days after inoculation had lower rates of placental-fetal abnormalities (25%–57%) but an additional 42% rate of complete pregnancy loss. Pregnancy loss (9%) and placental-fetal abnormalities (4%–7%) were uncommon in control animals. Rates of fetal abnormalities and placental infection in infected dams exceeded fetal viral infection, suggesting that TMEV infection adversely affects pregnancy either directly by fetal damage or indirectly by placental compromise.