Comparison of Dixon Sequences for Estimation of Percent Breast Fibroglandular Tissue.
Comparison of Dixon Sequences for Estimation of Percent Breast Fibroglandular Tissue.
复制标题
DOI：
10.1371/journal.pone.0152152
复制
发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Schmidt MA
中科院分区：
文献类型：
--
作者：
Ledger AE;Scurr ED;Hughes J;Macdonald A;Wallace T;Thomas K;Wilson R;Leach MO;Schmidt MA
目的评价两点Dixon序列脂肪-水分离磁共振成像(MRI)测量纤维腺组织百分比(%FGT)的误差来源。10名女性志愿者(年龄中位数：31岁，范围：23-50岁)在研究伦理委员会批准后给予知情同意。每位志愿者在重新定位后被扫描两次，以评估高分辨率梯度回波(GRE)质子密度(PD)加权Dixon序列的测量重复性。通过将该Dixon序列与低分辨率GRE PD加权Dixon数据以及基于梯度回波(GRE)或自旋回波(SE)的T1加权Dixon数据集进行比较，来评估可归因于分辨率、T1加权和序列类型的%FGT测量的差异。高分辨率PD加权Dixon序列的%FGT测量的重复性系数为±4.3%。高分辨率和低分辨率PD加权数据之间的%FGT没有显著差异。来自GRE和SE T1加权数据的%FGT与来自PD加权数据的%FGT具有很强的相关性(r分别为0.995和0.96)。然而，与PD加权数据相比，这两个序列的平均%FGT分别高出2.9%(p<；0.0001)和12.6%(p<；0.0001)；在较低的乳房密度下，SE T1加权序列的%fgt的增加明显更大。虽然在低分辨率下测量%FGT是可行的，但T1加权和序列类型会影响基于Dixon的%FGT测量的准确性；应该仔细考虑用于%FGT测量的Dixon MRI协议，特别是对于纵向或多中心研究。
To evaluate sources of error in the Magnetic Resonance Imaging (MRI) measurement of percent fibroglandular tissue (%FGT) using two-point Dixon sequences for fat-water separation. Ten female volunteers (median age: 31 yrs, range: 23–50 yrs) gave informed consent following Research Ethics Committee approval. Each volunteer was scanned twice following repositioning to enable an estimation of measurement repeatability from high-resolution gradient-echo (GRE) proton-density (PD)-weighted Dixon sequences. Differences in measures of %FGT attributable to resolution, T1 weighting and sequence type were assessed by comparison of this Dixon sequence with low-resolution GRE PD-weighted Dixon data, and against gradient-echo (GRE) or spin-echo (SE) based T1-weighted Dixon datasets, respectively. %FGT measurement from high-resolution PD-weighted Dixon sequences had a coefficient of repeatability of ±4.3%. There was no significant difference in %FGT between high-resolution and low-resolution PD-weighted data. Values of %FGT from GRE and SE T1-weighted data were strongly correlated with that derived from PD-weighted data (r = 0.995 and 0.96, respectively). However, both sequences exhibited higher mean %FGT by 2.9% (p < 0.0001) and 12.6% (p < 0.0001), respectively, in comparison with PD-weighted data; the increase in %FGT from the SE T1-weighted sequence was significantly larger at lower breast densities. Although measurement of %FGT at low resolution is feasible, T1 weighting and sequence type impact on the accuracy of Dixon-based %FGT measurements; Dixon MRI protocols for %FGT measurement should be carefully considered, particularly for longitudinal or multi-centre studies.