The drosophila melanogaster genome: translation factors and RNA binding proteins.

The drosophila melanogaster genome: translation factors and RNA binding proteins.
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DOI:
10.1083/jcb.150.2.f51
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发表时间:
2000-07-24
期刊:
The Journal of cell biology
影响因子:
--
通讯作者:
Lasko P
Lasko P
中科院分区:
其他
文献类型:
--
作者:
Lasko P

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黑腹果蝇基因组包括300个编码翻译因子或蛋白质的基因,这些基因具有良好特征的RNA结合基序。基本上所有的经典真核生物翻译因子都在它们的预测产物中被发现。RNA结合蛋白的四个最多的类别是RNA识别基序(RRM)1蛋白、DEAD/DExH盒解旋酶、KH结构域蛋白和双链RNA结合结构域(DSRBD)蛋白。这些中的许多容易对应于酵母或哺乳动物直系同源物,因此可以预测在前mRNA和前rRNA加工、翻译起始和RNA的核输出中具有特定功能。下面依次讨论编码胞质翻译因子的基因和编码每类RNA结合蛋白的基因。
The Drosophila melanogaster genome includes 300 genes encoding translation factors or proteins with wellcharacterized RNA binding motifs. Essentially all of the canonical eukaryotic translation factors were found among their predicted products. The four most numerous classes of RNA binding proteins are RNA recognition motif (RRM) 1 proteins, DEAD/DExH-box helicases, KH domain proteins, and double-stranded RNA binding domain (DSRBD) proteins. Many of these correspond readily to yeast or mammalian orthologs, and can therefore be predicted to have specific functions in pre-mRNA and prerRNA processing, translation initiation, and nuclear export of RNA. The genes encoding cytosolic translation factors, and those encoding each class of RNA binding protein, are discussed in turn below.
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发表时间: 1998-10-01
影响因子: 10.5
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