Association of Olfactory Bulb Volume and Olfactory Sulcus Depth with Olfactory Function in Patients with Parkinson Disease
Association of Olfactory Bulb Volume and Olfactory Sulcus Depth with Olfactory Function in Patients with Parkinson Disease
复制标题
帕金森病患者嗅球体积和嗅沟深度与嗅觉功能的关系
DOI：
10.3174/ajnr.a2350
复制
发表时间：
2011-04-01
影响因子：
3.5
通讯作者：
Guan, J.
中科院分区：
文献类型：
--
作者：
Wang, J.;You, H.;Guan, J.
背景与目的：嗅觉功能障碍通常与特发性帕金森病（IPD）相关。在此我们报道帕金森病（PD）患者嗅球（OB）体积和嗅沟（OS）深度与嗅觉功能的关联。
材料与方法：利用磁共振成像进行形态测量分析，并采用日本T&T嗅觉仪阈值测试来评估29例帕金森病患者以及29例年龄和性别匹配的健康对照者的嗅觉结构和功能。
结果：帕金森病患者的嗅觉识别阈值显著高于健康对照者（3.82±1.25比0.45±0.65，P
Before reading this article, I did not know that olfactory problems are as common as tremor in patients with Parkinson disease (70-90%). After rigidity/akinesia, olfactory dysfunction is the second most common symptom. Actually, Parkinson disease may be an olfactory disorder! Lewy bodies and subsequent atrophy happen initially in the olfactory bulbs and entorhinal cortex. The authors looked at olfactory bulb volume and depth of the olfactory sulci, correlated their findings with olfactometric tests, and compared their 20 patients with healthy controls. Abnormal volumes, depths, and olfaction tests were present in all patients with Parkinson disease but not in the controls. Their results provide evidence that early olfactory dysfunction in patients with Parkinson disease may be a primary consequence of damage to the olfactory bulb. Neuroimaging of olfactory structures together with the assessment of olfactory function may be used to identify patients with Parkinson disease. BACKGROUND AND PURPOSE: Olfactory dysfunction is commonly associated with IPD. We here report the association of OB volume and OS depth with olfactory function in patients with PD. MATERIALS AND METHODS: Morphometric analyses by using MR imaging and the Japanese T&T olfactometer threshold test were used to evaluate olfactory structure and function in 29 patients with PD and 29 age- and sex-matched healthy controls. RESULTS: The olfactory recognition thresholds were significantly higher in patients with PD than in healthy controls (3.82 ± 1.25 versus 0.45 ± 0.65, P < .001). Olfactory atrophy with reductions in the volume of the OB (37.30 ± 10.23 mm3 versus 44.87 ± 11.84 mm3, P < .05) and in the depth of OS (8.90 ± 1.42 mm versus 9.67 ± 1.24 mm, P < .05) was observed in patients with PD but not in controls. Positive correlations between olfactory performance and OB volumes were observed in both patients with PD (r = −0.45, P < .0001) and in controls (r = −0.42, P < .0001). In contrast, there was no significant correlation between the depth of OS and olfactory function in either cohort. CONCLUSIONS: The results provide evidence that early olfactory dysfunction in patients with PD may be a primary consequence of damage to the OB. Neuroimaging of olfactory structures together with the assessment of olfactory function may be used to identify patients with PD.