Preparation of Polyphosphate Porous Bioceramics and in vitro Cytocompatibility
Preparation of Polyphosphate Porous Bioceramics and in vitro Cytocompatibility
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DOI：
10.3724/sp.j.1077.2011.00759
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发表时间：
2011
影响因子：
1.7
通讯作者：
L. Bin;Dong Yin-sheng;Lin Pinghua;Zhang Jun;S. Jing
中科院分区：
文献类型：
--
作者：
L. Bin;Dong Yin-sheng;Lin Pinghua;Zhang Jun;S. Jing
以Al2O3-MgO-P2O5为粘结剂，采用泡沫浸渍法制备多孔陶瓷。采用扫描电镜（SEM）、x射线衍射（XRD）、阿基米德排水法和压缩试验研究了多孔材料的形貌、晶相、孔隙度和力学性能。发现磷酸Al2O3-MgO-P2O5促进了陶瓷的烧结，并均匀地改善了陶瓷浆料在泡沫表面的涂层。制备的陶瓷具有连接均匀的孔隙结构，大孔直径约为100 ~ 500μm，微孔直径约为3μm。平均孔隙率为85.9%±1.6%，抗压强度为（1.04±0.15）MPa。虽然烧结的多孔陶瓷是由HA、β-Ca2P2O7和Al、Mg等少数相组成的多磷磷酸盐。它们没有细胞毒性，并在体外刺激骨髓基质干细胞的增殖和分化。由此可见，这种多孔陶瓷具有良好的细胞亲和性和细胞相容性。
The porous ceramics were prepared by the foam impregnation technology using Al2O3-MgO-P2O5 as binder. Porous morphology, crystalline phase, porosity, and mechanical property were investigated by using scaning electron microscope (SEM), X-ray diffraction (XRD), Archimedes drainage method, and compression tests. It was found that Al2O3-MgO-P2O5 phosphate promoted the sintering of ceramics, and improved coating of ceramic slurry over the foams uniformly. The obtained ceramics have connective, uniform pore structures with macro-pores of about 100−500μm in diameter and micro-pores of about 3μm in diameter. Their average porosity and compressive strength were 85.9%±1.6% and (1.04±0.15) MPa respectively. Although sintered porous ceramics were polyphos- phates composed of HA, β-Ca2P2O7 and a few phases including Al and Mg. They had no cytotoxicity and provoked the proliferation and differentiation of marrow stromal stem cells in vitro. Thus it can be concluded that this kind of porous ceramics has good cellular affinity and cytocompatibility.