Intranodal Hemorrhagic Spindle‐Cell Tumor with “Amianthoid” Fibers: Report of Six Cases of a Distinctive Mesenchymal Neoplasm of the Inguinal Region That Simulates Kaposi's Sarcoma
Intranodal Hemorrhagic Spindle‐Cell Tumor with “Amianthoid” Fibers: Report of Six Cases of a Distinctive Mesenchymal Neoplasm of the Inguinal Region That Simulates Kaposi's Sarcoma
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结内出血性梭形细胞肿瘤，伴有“拟石榴”纤维：腹股沟区类似卡波西肉瘤的独特间叶性肿瘤六例报告
DOI：
10.1097/00000478-198905000-00002
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
J. Rosai
中科院分区：
文献类型：
--
作者：
S. Suster;J. Rosai
我们描述了6例独特的梭形细胞肿瘤显然来自腹股沟淋巴结的成年患者。病变的组织学特征为高度血管化，交织的梭形细胞束，周围有不规则的硬化和出血带，周围有淋巴结残留的压缩边缘。在所有病例中观察到的一个显著特征是存在含有厚胶原纤维（所谓的石棉纤维）的星状区域。免疫组化显示肿瘤细胞肌动蛋白、肌球蛋白和波形蛋白阳性。电子显微镜检查显示肌纤维母细胞和平滑肌分化的特征。随访未发现复发或转移的证据。病变表现为良性生物学行为的间充质细胞的结节内肿瘤性增生。腹股沟的位置，石棉纤维的存在，和周围的梭形细胞增殖出血的醒目边缘设置这个肿瘤除了其他病变。重要的是要将该实体与卡波西肉瘤的淋巴结受累区分开来，卡波西肉瘤可能与淋巴结受累非常相似。
We describe six cases of a distinctive spindle-cell neoplasm apparently arising from inguinal lymph nodes in adult patients. The lesions were characterized histologically by highly vascularized, interlacing fascicles of spindle cells circumscribed by an irregular band of sclerosis and hemorrhage, and surrounded by a compressed rim of lymph node remnant. A striking feature observed in all cases was the presence of stellate-shaped areas containing thick collagen fibers (so-called amianthoid fibers). Immunohistochemically, the tumor cells were positive for actin, muscle myosin, and vimentin. Electron-microscopic examination demonstrated features indicative of myofibroblastic and smooth-muscle differentiation. Follow-up has shown no evidence of recurrence or metastases. The lesions appear to represent an intranodal neoplastic proliferation of mesenchymal cells exhibiting benign biologic behavior. The inguinal location, presence of amianthoid fibers, and the striking rim of hemorrhage surrounding the spindle-cell proliferation set this tumor apart from other lesions. It is important to distinguish this entity from nodal involvement by Kaposi's sarcoma, a lesion it may closely resemble.