Neural correlates of impulsive aggressive behavior in subjects with a history of alcohol dependence.
Neural correlates of impulsive aggressive behavior in subjects with a history of alcohol dependence.
复制标题
DOI：
10.1037/bne0000038
复制
发表时间：
2015-04
影响因子：
1.9
通讯作者：
Lane SD
中科院分区：
文献类型：
--
作者：
Kose S;Steinberg JL;Moeller FG;Gowin JL;Zuniga E;Kamdar ZN;Schmitz JM;Lane SD
与酒精有关的攻击是一个复杂和有问题的现象，具有深刻的公共卫生后果。我们研究了可能调节人类攻击行为和慢性饮酒之间关系的神经相关性。13名符合DSM-IV标准的既往酒精依赖缓解期（AD）受试者和13名匹配的健康对照（CONT）参与了一项根据人类攻击行为实验室模型（点减法攻击范式，或PSAP）改编的fMRI研究。血氧水平依赖性（BOLD）激活过程中的操作定义的攻击性行为，在postoffensive期间，并在货币强化的行为。全脑体素随机效应分析发现，与长期饮酒和攻击行为相关的大脑区域存在组间差异（例如，情绪和行为控制）。在行为上，AD受试者对攻击性反应和货币反应选项的反应率显着高于CONT。全脑voxelwise随机效应分析显示显着的组差异，在响应挑衅（货币减法），与CONT科目表现出更大的激活，在额叶和前额叶皮层，丘脑和海马。所有受试者的数据崩溃，回归分析后激发脑激活的攻击性反应率显示显着的正回归斜率在中央前回和顶叶皮质，和显着的负回归斜率在眶额皮质，前额皮质，尾状核，丘脑，颞中回。在这些崩溃的分析中，对挑衅和攻击行为的反应与抑制和情绪控制、感觉运动整合和目标导向运动活动的大脑区域的激活有关。
Alcohol-related aggression is a complex and problematic phenomenon with profound public health consequences. We examined neural correlates potentially moderating the relationship between human aggressive behavior and chronic alcohol use. Thirteen subjects meeting DSM–IV criteria for past alcohol-dependence in remission (AD) and 13 matched healthy controls (CONT) participated in an fMRI study adapted from a laboratory model of human aggressive behavior (Point Subtraction Aggression Paradigm, or PSAP). Blood oxygen level dependent (BOLD) activation was measured during bouts of operationally defined aggressive behavior, during postprovocation periods, and during monetary-reinforced behavior. Whole brain voxelwise random-effects analyses found group differences in brain regions relevant to chronic alcohol use and aggressive behavior (e.g., emotional and behavioral control). Behaviorally, AD subjects responded on both the aggressive response and monetary response options at significantly higher rates than CONT. Whole brain voxelwise random-effects analyses revealed significant group differences in response to provocation (monetary subtractions), with CONT subjects showing greater activation in frontal and prefrontal cortex, thalamus, and hippocampus. Collapsing data across all subjects, regression analyses of postprovocation brain activation on aggressive response rate revealed significant positive regression slopes in precentral gyrus and parietal cortex; and significant negative regression slopes in orbitofrontal cortex, prefrontal cortex, caudate, thalamus, and middle temporal gyrus. In these collapsed analyses, response to provocation and aggressive behavior were associated with activation in brain regions subserving inhibitory and emotional control, sensorimotor integration, and goal directed motor activity.