Depressed visual field and mood are associated with sleep disorder in glaucoma patients.
Depressed visual field and mood are associated with sleep disorder in glaucoma patients.
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DOI：
10.1038/srep25699
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发表时间：
2016-05-11
影响因子：
4.6
通讯作者：
Tsubota K
中科院分区：
文献类型：
--
作者：
Ayaki M;Shiba D;Negishi K;Tsubota K
本研究的目的是评估青光眼患者的睡眠和情绪障碍以及相关的眼部参数。我们关注视野和视网膜神经纤维层，因为青光眼中可能存在由受损的固有光敏视网膜神经节细胞引起的昼夜光感受性降低。对140名受试者进行了横断面研究：69名青光眼患者和71名正常对照者。患有白内障、干眼症或视网膜病变的个体被排除在研究之外。参与者完成了匹兹堡睡眠质量指数（PSQI）和医院焦虑和抑郁量表（HADS），并接受了青光眼的全面眼科检查。晚期青光眼患者PSQI评分明显低于正常对照组（P < 0.05）。多元逐步线性回归分析显示，校正年龄和性别后，PSQI与HADS中最差眼的平均偏差、用药次数和频率、焦虑和抑郁分显著相关（P < 0.05）。PSQI评分与视网膜神经纤维层厚度无明显相关性。结论青光眼患者的主观睡眠质量与视野缺损和情绪状态相关。
The aim of the present study was to evaluate sleep and mood disorders and related ocular parameters in glaucoma patients. We focused on visual fields and the retinal nerve fibre layer, because decreased circadian photoreception by damaged intrinsically photosensitive retinal ganglion cells is suspected in glaucoma. A cross-sectional study was performed on 140 subjects: 69 with glaucoma and 71 normal controls. Individuals with cataract, dry eye, or retinal pathology were excluded from the study. Participants completed the Pittsburgh Sleep Quality Index (PSQI) and Hospital Anxiety and Depression Scale (HADS) and underwent comprehensive ophthalmological examinations for glaucoma. Patients with advanced glaucoma had significantly worse PSQI scores than normal controls (P < 0.05). Stepwise multivariate linear regression analysis revealed PSQI was significantly correlated with the mean deviation in the worse eye, the number and frequency of medications, and anxiety and depression subscores of the HADS after adjustment for age and sex (P < 0.05). We did not find a significant correlation between PSQI scores and the thickness of retinal nerve fibre layer. In conclusion, the subjective sleep quality of glaucoma patients was correlated with visual field loss and mood status.