ROLE OF LYSOSOMES AND OF CELL MEMBRANES IN PHOTOSENSITIZATION
ROLE OF LYSOSOMES AND OF CELL MEMBRANES IN PHOTOSENSITIZATION
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DOI：
10.1038/209874a0
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发表时间：
1966-01-01
期刊：
影响因子：
64.8
通讯作者：
YOUNG, MR
中科院分区：
文献类型：
--
作者：
ALLISON, AC;MAGNUS, IA;YOUNG, MR
使用经典光敏剂，在大鼠肠系膜和猪皮肤体内研究光敏机制，并在体外使用红细胞、精子和各种细胞培养物研究光敏机制。结论是，初始事件是光动力诱导的内皮细胞和可能邻近的结缔组织细胞的溶酶体通透性增加，并释放一种或多种化学介质。-P.J.B.
Using classical photosensitizing agents, the mechanism of photosensitization was studiedin vivoin the rat mesentery and g.pig skin, andin vitrousing r.b.c., spermatozoa and various cell cultures. It is concluded that the initial event is a photo-dynamically-induced increase in permeability of lysosomes of endothelial and possibly adjacent connective tissue cells, with release of one or more chemical mediators.-P.J.B.