CEREBRAL-PALSY IN MULTIPLE BIRTHS IN WESTERN AUSTRALIA - GENETIC-ASPECTS
CEREBRAL-PALSY IN MULTIPLE BIRTHS IN WESTERN AUSTRALIA - GENETIC-ASPECTS
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DOI：
10.1002/ajmg.1320370311
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发表时间：
1990-11-01
期刊：
影响因子：
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通讯作者：
HENDERSON, D
中科院分区：
文献类型：
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作者：
PETTERSON, B;STANLEY, F;HENDERSON, D
对多胎婴儿的大脑活动进行了一项研究，以测试基因参与，并评估在这些情况下怀孕和分娩的特殊条件的影响。从西澳大利亚州脑瘫登记处获得了1956至1985年间西澳大利亚州发生的多胎妊娠脑性瘫痪的完全确证。共有74对双胞胎和5个三胞胎。关于性别、出生顺序、运动障碍、同卵双胞胎和三胞胎的结局、合子和家系信息的数据从登记簿、医院记录中获得，如果可能的话，通过与申请人的父母(S)的面谈获得。MZ双生子的符合率显著高于DZ双生子(P=0.0026)。然而，家系研究表明，没有其他亲属患有与先证者类似的运动障碍。至少在某些情况下，这与多因素的原因是一致的。受影响的双胞胎的性别比为2.1，而单胞胎的性别比为1.3，所有5个受影响的三胞胎都是男孩。在1%的水平上，性别比随复数的增加而增加的趋势显著。
A study of cerebral plays in multiple births was undertaken to test genetic involvement and assess the impact of the special conditions of pregnancy and parturition in these cases. Complete ascertainment of cerebral palsy in multiple gestations tht occurred in Western Australia between 1956 and 1985 was obtained from the Western Australian Cerebral Palsy Register. There were 74 twins and 5 triplets. Data on sex, birth order, motor handicap, outcome in co-twins and triplets, zygosity, and pedigree information was obtained from the Register, hospital records, and, where possible, by interview of the parent(s) of the propositi. There was a significantly higher (P = 0.0026) concordance rate in MZ than in DZ twin pairs. However, pedigree studies showed no other relatives with a motor handicap similar to that of the propositi. This is consistent with a multifactorial cause in at least some of the cases. The sex ratio of affected twins was found to be 2.1 compared to 1.3 for singletons and all 5 affected triplets were boys. The trend of increasing sex ratio with increasing plurality was significant at the 1% level.