Palladium-Catalyzed Cross Addition of Terminal Alkynes to Aryl Ynamides: An Unusual trans-Hydroalkynylation Reaction
Palladium-Catalyzed Cross Addition of Terminal Alkynes to Aryl Ynamides: An Unusual trans-Hydroalkynylation Reaction
复制标题
钯催化末端炔烃与芳基酰胺的交叉加成：一种不寻常的反式氢炔化反应
DOI：
10.1002/adsc.201400572
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发表时间：
2014-11-03
影响因子：
5.4
通讯作者：
Zhu, Gangguo
中科院分区：
文献类型：
--
作者：
Liu, Ge;Kong, Wei;Zhu, Gangguo
首次实现了钯催化n -磺酰基酰胺的反式氢烷基化反应，提供了高收率的α -烷基化加合物，具有优异的区域选择性和立体选择性。所得的烯产物可作为铂催化环异构化反应制备萘衍生物的有用前驱体。
A palladium-catalyzed trans-hydroalkynylation of N-sulfonyl ynamides has been achieved for the first time, providing alpha-alkynylation adducts in high yields with excellent regio- and stereoselectivity. The resulting enyne products can serve as the useful precursors for the elaboration of naphthalene derivatives via a platinum-catalyzed cycloisomerization reaction.