Pacemaker Created in Human Ventricle by Depressing Inward-Rectifier K⁺ Current: A Simulation Study.
Pacemaker Created in Human Ventricle by Depressing Inward-Rectifier K⁺ Current: A Simulation Study.
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通过抑制内向整流器 K 电流在人心室中制造起搏器：模拟研究
DOI：
10.1155/2016/3830682
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发表时间：
2016
影响因子：
--
通讯作者：
Zhang H
中科院分区：
文献类型：
--
作者：
Zhang Y;Wang K;Li Q;Zhang H
心脏传导障碍是引起心率减慢和晕厥的常见疾病。目前治疗这些疾病的最好方法是植入电子起搏器，但它也有许多缺点，如电池寿命有限和感染。生物起搏器有望取代电子设备。自主心室肌细胞（VM）可出现起搏活动，这种活动是通过抑制内向整流钾电流（IK1）而引起的。在这项研究中，一个2D模型的人类生物起搏器创建从心室内膜心肌细胞。我们检查了所创建的生物起搏器的稳定性，并通过找到合适的起搏器尺寸和空间分布来研究其驱动能力，以实现稳健的起搏并驱动周围的静止心肌细胞。我们的结果表明，起搏器的节律与最终稳定状态的单个细胞的节律相似。生物起搏器的驱动力与起搏器的空间分布模式密切相关。
Cardiac conduction disorders are common diseases which cause slow heart rate and syncope. The best way to treat these diseases by now is to implant electronic pacemakers, which, yet, have many disadvantages, such as the limited battery life and infection. Biopacemaker has been expected to replace the electronic devices. Automatic ventricular myocytes (VMs) could show pacemaker activity, which was induced by depressing inward-rectifier K+ current (I K1). In this study, a 2D model of human biopacemaker was created from the ventricular endocardial myocytes. We examined the stability of the created biopacemaker and investigated its driving capability by finding the suitable size and spatial distribution of the pacemaker for robust pacing and driving the surrounding quiescent cardiomyocytes. Our results suggest that the rhythm of the pacemaker is similar to that of the single cell at final stable state. The driving force of the biopacemaker is closely related to the pattern of spatial distribution of the pacemaker.