Activity of Primate Orbitofrontal and Dorsolateral Prefrontal Neurons: Effect of Reward Schedule on Task-related Activity
Activity of Primate Orbitofrontal and Dorsolateral Prefrontal Neurons: Effect of Reward Schedule on Task-related Activity
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DOI：
10.1162/jocn.2008.20047
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发表时间：
2008-04-01
影响因子：
3.2
通讯作者：
Funahashi, Shintaro
中科院分区：
文献类型：
--
作者：
Ichihara-Takeda, Satoe;Funahashi, Shintaro
最近的研究表明，任务相关的活动在背外侧前额叶皮层（DLPFC）调制的质量和数量的奖励，这表明受试者的动机状态影响认知操作的DLPFC。眶额皮质（OFC）是一个可能的来源，动机输入DLPFC。然而，这两个领域是否表现出类似的任务相关活动的激励效果还不清楚。我们比较了在这些领域的任务相关的活动，而猴子进行了眼延迟反应（ODR）任务下的两个奖励计划的激励效果。在ODR-1时间表中，只有在成功完成四次连续试验后才给予奖励，而在ODR-2时间表中，每次正确试验后都给予奖励。在这两个领域开展的与任务有关的活动都表现出空间选择性。任务相关活动的空间特征在两个时间表中保持不变。在这两个领域的任务相关的活动，特别是延迟期活动，也受到奖励时间表和活动的幅度逐渐增加，这取决于在ODR-1时间表的奖励试验的接近。任务相关的眶额皮层活动更多地受到奖励时间表的影响，而任务相关的后额叶皮层活动更多地受到空间因素和奖励时间表的影响。这些结果表明，眶额皮层在监测奖励试验的接近程度和检测奖励传递方面发挥着作用，而DLPFC在执行认知操作和整合认知和动机信息方面发挥着作用。这些结果还表明，空间信息和动物的动机状态独立地影响这两个领域的神经元活动。
Recent studies show that task-related activity in the dorsolateral prefrontal cortex (DLPFC) is modulated by the quality and quantity of the reward, suggesting that the subject's motivational state affects cognitive operations in the DLPFC. The orbitofrontal cortex (OFC) is a possible source of motivational inputs to the DLPFC. However, it is not well known whether these two areas exhibit similar motivational effects on task-related activity. We compared motivational effects on task-related activity in these areas while a monkey performed an oculomotor delayed-response (ODR) task under two reward schedules. In the ODR-1 schedule, reward was given only after the successful completion of four consecutive trials, whereas in the ODR-2 schedule, reward was given after every correct trial. Task-related activities in both areas showed spatial selectivity. The spatial characteristics of task-related activity remained constant in both schedules. Task-related activity in both areas, especially delay-period activity, was also affected by the reward schedule and the magnitude of the activity gradually increased depending on the proximity of the reward trial in the ODR-1 schedule. More task-related OFC activities were affected by reward schedules, whereas more task-related DLPFC activities were affected by spatial factors and reward schedules. These results indicate that the OFC plays a role in monitoring the proximity of the reward trial and detecting reward delivery, whereas the DLPFC plays a role in performing cognitive operations and integrating cognitive and motivational information. These results also indicate that spatial information and the animal's motivational state independently affect neuronal activity in both areas.