Substantia nigra tangles are related to gait impairment in older persons
Substantia nigra tangles are related to gait impairment in older persons
复制标题
DOI：
10.1002/ana.20723
复制
发表时间：
2006-01-01
影响因子：
11.2
通讯作者：
Bennett, DA
中科院分区：
文献类型：
--
作者：
Schneider, JA;Li, JL;Bennett, DA
目的：帕金森病体征，尤其是步态障碍，在老年人中很常见，并与发病率和死亡率相关。我们的目的是检验黑质神经元缠结（NFT）与老年痴呆和非痴呆患者帕金森症状相关的假设。研究方法：我们研究了86名已故的老年天主教神职人员，没有原发性帕金森病的宗教秩序研究，纵向临床病理研究。平均死亡年龄为85.3岁。步态障碍，运动迟缓，僵硬，震颤的迹象进行了评估接近死亡使用修改的统一帕金森氏病评定量表。在tau免疫组织化学之前，将黑质的40微米石蜡包埋切片漂白，并使用光学disector对NFT进行计数。我们使用多变量线性回归来检查帕金森病体征作为黑质NFT的函数，控制年龄，性别，教育和皮质NFT。结果：黑质。86例患者中有67例（77.9%）存在NFT。在控制了年龄、性别、教育和皮质NFT后，黑质NFT与步态障碍相关（p < 0.001），但与运动迟缓、僵硬或震颤无关。结果未受到痴呆、Braak评分、神经抑制剂药物、脑梗死或路易体的混淆。解释：黑质中的NFT与老年痴呆和非痴呆患者的步态障碍相关。
Objective: Parkinsonian signs, especially gait impairment, are common and associated with morbidity and mortality in older persons. Our objective was to test the hypothesis that substantia nigra neurofibrillary tangles (NFTs) are related to parkinsonian signs in older persons with and without dementia. Methods: We studied 86 deceased older Catholic clergy without idiopathic Parkinson's disease from the Religious Order Study, a longitudinal clinical-pathological study. Mean age at death was 85.3 years. Signs of gait disturbance, bradykinesia, rigidity, and tremor were assessed proximate to death using a modified Unified Parkinson's Disease Rating Scale. Forty-micrometer paraffin-embedded sections of substantia nigra were bleached before tau immunohistochemistry and the optical disector was used to count NFTs. We used multivariable linear regression to examine parkinsonian signs as a function of nigra NFTs, controlling for age, sex, education, and cortical NFTs. Results: Substantia nigra. NFTs were present in 67 of 86 persons (77.9%). After controlling for age, sex, education, and cortical NFTs, nigra NFTs were related to gait impairment (p < 0.001), but not bradykinesia, rigidity, or tremor. Results were not confounded by dementia, Braak score, neuroleptic medication, cerebral infarcts, or Lewy bodies. Interpretation : NFTs in the substantia nigra are associated with gait impairment in older persons with and without dementia.