Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations
Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations
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DOI：
10.1038/ng.301
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发表时间：
2009-02-01
期刊：
影响因子：
30.8
通讯作者：
Froguel, Philippe
中科院分区：
文献类型：
--
作者：
Meyre, David;Delplanque, Jerome;Froguel, Philippe
我们分析了 1,380 名患有早发性和病态成人肥胖症的欧洲人以及 1,416 名年龄匹配的正常体重对照者的全基因组关联数据。在 14,186 名欧洲受试者中进一步评估了 38 个显示出强相关性的标志物。除了FTO和MC4R之外，我们还检测到肥胖与NPC1（内体/溶酶体Niemann-Pick C1基因，P = 2.9 x 10(-7)）、MAF附近（编码转录因子c-MAF，P 3.8 x 10(-13)）附近和PTER（磷酸三酯酶相关基因，P = 2.1 x）附近的三个新风险位点显着相关。 10(-7))。
We analyzed genome-wide association data from 1,380 Europeans with early-onset and morbid adult obesity and 1,416 age-matched normal-weight controls. Thirty-eight markers showing strong association were further evaluated in 14,186 European subjects. In addition to FTO and MC4R, we detected significant association of obesity with three new risk loci in NPC1 (endosomal/lysosomal Niemann-Pick C1 gene, P = 2.9 x 10(-7)), near MAF (encoding the transcription factor c-MAF, P 3.8 x 10(-13)) and near PTER (phosphotriesterase-related gene, P = 2.1 x 10(-7)).