Vascular aging, the vascular cytoskeleton and aortic stiffness.
Vascular aging, the vascular cytoskeleton and aortic stiffness.
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DOI：
10.37349/emed.2021.00041
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发表时间：
2021
影响因子：
--
通讯作者：
Morgan KG
中科院分区：
文献类型：
--
作者：
Kajuluri LP;Singh K;Morgan KG
血管老化、主动脉僵硬和高血压在机制上是相互关联的。本文提出的观点将主要集中在与年龄相关的血管平滑肌细胞（VSMC）硬度增加的分子机制上。本文就VSMC参与血管衰老紊乱的机制作一综述。将详细介绍血管细胞的不同功能子组分以及老化主动脉中蛋白质-蛋白质相互作用的分子机制、信号机制和细胞内运输过程。
Vascular aging, aortic stiffness and hypertension are mechanistically interrelated. The perspective presented here will focus mainly on the molecular mechanisms of age-associated increases in the stiffness of the vascular smooth muscle cell (VSMC). This review will highlight the mechanisms by which the VSMC contributes to disorders of vascular aging. Distinct functional sub-components of the vascular cell and the molecular mechanisms of the protein-protein interactions, signaling mechanisms and intracellular trafficking processes in the setting of the aging aorta will be detailed.