Parabrachial gustatory lesions impair taste aversion learning in rats.
Parabrachial gustatory lesions impair taste aversion learning in rats.
复制标题
臂旁味觉损伤损害大鼠的味觉厌恶学习。
DOI：
10.1037//0735-7044.106.1.147
复制
发表时间：
1992
影响因子：
1.9
通讯作者：
Grill,HJ
中科院分区：
文献类型：
--
作者：
Spector,AC;Norgren,R;Grill,HJ
臂旁核(PBN)味觉区的损伤严重损害了大鼠条件性味觉厌恶(CTA)的获得。为了验证这种缺陷是否有记忆基础，正常大鼠(n=15)和PBN损毁大鼠(n=10)在注射氯化锂或氯化钠后，在30.5min内注入7次味觉刺激(30 S，0.5ml)。此任务测量CTA的快速形成，并且对内存的要求最低。注射LiCl2的正常大鼠逐渐改变了它们的运动反应特征，从摄取型变为厌恶型。注射氯化钠的完整大鼠没有改变它们的摄食反应模式。相比之下，氯化锂和氯化钠注射的PBNX大鼠之间没有差异。当在不同的范式中测试时，这些相同的PBNX大鼠未能避免舔食味觉刺激。纪念过程中的简单损害不太可能是CTA赤字的基础。
Lesions in the gustatory zone of the parabrachial nuclei (PBN) severely impair acquisition of a conditioned taste aversion (CTA) in rats. To test whether this deficit has a memorial basis, intact rats (n= 15) and rats with PBN lesions (PBNX; n= 10) received seven intraoral taste stimulus infusions (30 s, 0.5 ml) distributed over a 30.5-min period after either LiCl or NaCl injection. This task measures the rapid formation of a CTA and has minimum demands on memory. LiCl-injected intact rats progressively changed their oromotor response profile from one of ingestion to one of aversion. NaCl-injected intact rats did not change their ingestive pattern of responding. In contrast, there was no difference between LiCl-and NaCl-injected PBNX rats. These same PBNX rats failed to avoid licking the taste stimulus when tested in a different paradigm. A simple impairment in a memorial process is not likely the basis for the CTA deficit.