Staphylococcus colonization of the skin and antimicrobial peptides.
Staphylococcus colonization of the skin and antimicrobial peptides.
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DOI：
10.1586/edm.10.6
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发表时间：
2010-04
期刊：
影响因子：
--
通讯作者：
Otto M
中科院分区：
文献类型：
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作者：
Otto M
葡萄球菌是最丰富的皮肤定植细菌，也是医院感染和社区相关皮肤感染的最重要原因。葡萄球菌皮肤定植的分子决定因素包括促进粘附和聚集的表面聚合物和蛋白质，以及逃避获得性和先天宿主防御的多种机制。抗菌肽 (AMP) 可能在提供对人类上皮细胞定植的细菌免疫力方面发挥着核心作用。最近的研究表明，葡萄球菌具有广泛的武器库来对抗 AMP 活性，并且可以根据 AMP 的存在调节 AMP 抗性机制的表达。虽然仍然缺乏直接的体内证据，但这表明进化过程中 AMP 和 AMP 抗性机制之间的相互作用对于使葡萄球菌成为人类皮肤的有效定植者具有至关重要的作用。
Staphylococci are the most abundant skin-colonizing bacteria and the most important causes of nosocomial infections and community-associated skin infections. Molecular determinants of staphylococcal skin colonization include surface polymers and proteins that promote adhesion and aggregation, and a wide variety of mechanisms to evade acquired and innate host defenses. Antimicrobial peptides (AMPs) likely play a central role in providing immunity to bacterial colonization on human epithelia. Recent research has shown that staphylococci have a broad arsenal to combat AMP activity, and can regulate expression of AMP-resistance mechanisms depending on the presence of AMPs. While direct in vivo evidence is still lacking, this suggests that the interplay between AMPs and AMP resistance mechanisms during evolution had a crucial role in rendering staphylococci efficient colonizers of human skin.