A targeted and nontargeted metabolomics study on the oral processing of epicatechins from green tea
A targeted and nontargeted metabolomics study on the oral processing of epicatechins from green tea
复制标题
绿茶中表儿茶素口服加工的靶向和非靶向代谢组学研究
DOI：
10.1016/j.foodchem.2022.132129
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发表时间：
2022-01-15
期刊：
影响因子：
8.8
通讯作者：
Xu, Yong-Quan
中科院分区：
文献类型：
--
作者：
Cao, Qing-Qing;Fu, Yan-Qing;Xu, Yong-Quan
Oral processing (OP), referring to the whole process of food digestion in human mouth, has a major influence on food flavor perception. This study focused on the compositional changes of the four green tea epicatechins (viz., EC, EGC, ECG, EGCG) during OP, based on targeted and nontargeted metabolomics. It was found that the four epicatechins were all extensively lost through transformation undergoing OP, among which EC was the most stable one, whereas EGCG the least. EGCG was further revealed to be susceptible to human oral cavity in the simulated OP in vitro. It could be converted physically by precipitating with mucin in saliva, and chemically through hydrolysis and dimerization, mediated mainly by the neutral pH condition. The OP of epicatechins also caused salivary composition changes possibly involving health benefits of green tea. These findings could raise awareness of the interactions between epicatechins, or any other food materials, with human mouth.
