Time course of arterial wall changes with DOCA plus salt hypertension in the rat.
Time course of arterial wall changes with DOCA plus salt hypertension in the rat.
复制标题
DOCA加盐高血压大鼠动脉壁的时程变化。
DOI：
10.1161/01.hyp.4.1.27
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Cox,RH
中科院分区：
文献类型：
--
作者：
Cox,RH
来自对照和高血压动物（DOCA +盐）的颈动脉和尾动脉以及胸主动脉的节段用于力学和/或化学组成的研究。在主动（145 mM-K+）和被动（O-Ca++和2 mM-EGTA）平滑肌条件下对完整节段进行压力-直径测量。节段用于结缔组织含量、水空间和电解质含量的化学分析。颈动脉和尾动脉的被动刚度随时间单调增加。颈动脉在高血压2周后出现明显变化，而尾动脉仅在12周后出现明显变化。高血压动脉的胶原和总结缔组织含量减少，而胶原/弹性蛋白不变。平滑肌激活产生更大的变化，高血压动脉的直径，特别是在较高的跨壁压值。从+2周开始的每个时间段，颈动脉的最大主动力发展都有所增加，而尾动脉的最大主动力发展仅在+2周和+4周增加。这些动脉的相对细胞体积单调增加与高血压。对照组和DOCA组大鼠颈动脉的最大主动力与细胞含量无显著差异。对于在此基础上正常化的高血压尾动脉，力发展在+4周时保持升高，但在+12周时显著降低。并不是所有的平滑肌激活的反应是单调的高血压的持续时间，也不能解释所有这些变化的基础上的细胞体积的变化。
Segments of carotid and tail artery, and thoracic aorta from control and hypertensive animals (DOCA + salt) were used for the study of mechanics and/or chemical composition. Pressure-diameter measurements were made on intact segments under conditions of active (145 mM-K+) and passive (O-Ca++ and 2 mM-EGTA) smooth muscle. Segments were used for chemical analyses of connective tissue content, water spaces, and electrolyte content. The passive stiffness of carotid and tail arteries increased monotonically with time. The carotids showed significant changes after two weeks of hypertension while the tail arteries only after 12 weeks. The collagen and total connective tissue content of the hypertensive arteries was decreased while collagen/elastin was unchanged. Smooth muscle activation produced larger changes in diameter of hypertensive arteries especially at higher values of transmural pressure. Maximum active force development was increased in carotid arteries at each time period from +2 weeks on while it was increased for the tail arteries only at +2 and +4 weeks. Relative cellular volume of these arteries was monotonically increased with hypertension. Maximum active force normalized to cellular content was not significantly different for carotid arteries from control and DOCA rats. For hypertensive tail arteries normalized on this basis force development remained elevated at +4 weeks but was significantly reduced at +12 weeks. Not all of the response to smooth muscle activation are monotonic with duration of hypertension, nor can all of these changes be explained on the basis of changes in cellular volume.